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Methyltetrazine-Ph-NHS ester

Methyltetrazine-Ph-NHS ester
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based linker used in synthesizing PROTACs (proteolysis-targeting chimeras)[1].
Catalog No. T16063Cas No. 1644644-96-1

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Methyltetrazine-Ph-NHS ester

Catalog No. T16063Cas No. 1644644-96-1

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based linker used in synthesizing PROTACs (proteolysis-targeting chimeras)[1].
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Product Introduction

Bioactivity
Description
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based linker used in synthesizing PROTACs (proteolysis-targeting chimeras)[1].
In vitro
PROTACs, containing two distinct ligands linked together—one targeting an E3 ubiquitin ligase and the other the target protein—utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight327.29
FormulaC15H13N5O4
Cas No.1644644-96-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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