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L-365260

Name: L-365260
Brand: TargetMol
SKU: T22895
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22895Cas No. 118101-09-0

Alias L365260, L-365,260, L 365260

L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases.

L-365260

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Purity: 99.75%

Catalog No. T22895Alias L365260, L-365,260, L 365260Cas No. 118101-09-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.75%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	L-365260 is an orally available, selective and potent nonpeptide gastrin and cerebral cholecystokinin receptor (CCK-B) antagonist.L-365260 inhibits CCK-8S-induced increase in [Ca2+]i, blocks stress-induced hypersensitivity in viscera, and blocks the anti-exploratory effect of CCK-4.L-365260 has been used in the study of neurological Ojibwa and endocrine diseases.
Targets&IC50	Gastrin:1.9 nM (Ki), Gastrin/CCK-B:2.0 nM (Ki)
In vitro	L-365260 is a compound with high affinity for CCK-B receptors in the brains of various species, which significantly attenuates CCK8S- and CCK4-mediated neuronal depolarization, and has lower affinity for CCK-B and gastrin receptors in dog tissues[1].
In vivo	In male Sprague-Dawley rats (300-350 g), L-365260 (0.01, 0.05, 0.1, 0.2, 0.75, 1.0, 10.0 mg/kg; subcutaneous injection) enhances the analgesic effects[3].
Synonyms	L365260, L-365,260, L 365260

Chemical Properties

Molecular Weight	398.46
Formula	C₂₄H₂₂N₄O₂
Cas No.	118101-09-0
Smiles	CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(C)c2)C1=O)c1ccccc1
Relative Density.	1.23g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: <39.85 mg/mL, Sonication is recommended.

DMSO: 80 mg/mL (200.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5097 mL	12.5483 mL	25.0966 mL	125.4831 mL
5 mM	0.5019 mL	2.5097 mL	5.0193 mL	25.0966 mL
10 mM	0.2510 mL	1.2548 mL	2.5097 mL	12.5483 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2742 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5097 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc