Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect.
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Description | Guanfu base I is an active metabolite of Guanfu base A, isolated from Aconitum coreanum. It have a potent anti-arrhythmic effect. |
In vivo | The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined.?The method is linear in the 0.05-20 μg/mL concentration range.?The recovery of Guanfu base I is more than 80%.?The intraday and interday precision, expressed as the relative standard deviation, is generally good.?After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours.?The total plasma clearance value is 1.46 L/h/kg.?After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour.?The absolute bioavailability of Guanfu base I is 71.31%. |
Synonyms | Acorine |
Molecular Weight | 387.476 |
Formula | C22H29NO5 |
CAS No. | 110225-59-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Guanfu base I 110225-59-7 Others Acorine inhibitor inhibit