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GENZ-882706

Catalog No. T11390 CAS 2070864-35-4

Synonyms: RA03546849

GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GENZ-882706, CAS 2070864-35-4

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,130.00
50 mg	10-14 weeks	$ 2,770.00
100 mg	10-14 weeks	$ 4,470.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

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Description	GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
In vitro	Genz-882706 induces an increased level of proliferative activity on unstimulated cells 48 hours post treatmen.
In vivo	Daily administration of Genz-882706 markedly attenuates experimental autoimmune encephalomyelitis (EAE) severity. In EAE-affected mice, Genz-882706 significantly lowers MCP-1, IL-6, IL-1β, and IP-10 levels in spinal cord homogenates, contrasting sharply with those treated with a vehicle. Conversely, TNF-α levels in the spinal cord notably increase following Genz-882706 treatment compared to the vehicle group. Furthermore, Genz-882706 administrations, at both 30 mg/kg and 100 mg/kg dosages, substantially decrease the population of microglia and monocytes/macrophages in the brain and spinal cord, standing out from vehicle and LPS controls. Additionally, Genz-882706 modestly diminishes CD80 expression on monocytes/macrophages within the brain.

Synonyms	RA03546849
Molecular Weight	455.51
Formula	C26H25N5O3
CAS No.	2070864-35-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kane, et al. Colony Stimulating Factor-1 Receptor (CSF-1R) Inhibitors. WO 2017015267A1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GENZ-882706 2070864-35-4 Tyrosine Kinase/Adaptors CSF-1R RA 03546849 GENZ 882706 RA-03546849 RA03546849 GENZ882706 inhibitor inhibit

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