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Evogliptin tartrate

Catalog No. T11248   CAS 1222102-51-3
Synonyms: DA-1229 tartrate

Evogliptin tartrate has potential for anti-atherosclerosis therapy that targets arterial inflammation. Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with antidiabetic activity.

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Evogliptin tartrate Chemical Structure
Evogliptin tartrate, CAS 1222102-51-3
Pack Size Availability Price/USD Quantity
5 mg 6-8 weeks $ 332.00
25 mg 6-8 weeks $ 1,080.00
50 mg 6-8 weeks $ 1,410.00
100 mg 6-8 weeks $ 1,990.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Evogliptin tartrate has potential for anti-atherosclerosis therapy that targets arterial inflammation. Evogliptin tartrate is a potent, orally bioavailable and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, with antidiabetic activity.
In vitro Evogliptin tartrate inhibits the TNF-α-mediated transcriptional activation of ICAM-1 and VCAM-1. Evogliptin tartrate inhibits inflammatory responses via suppression of adhesion molecules induced by TNF-α. And TNF-α-mediated activation of NF-κB is ameliorated by evogliptin via the interaction of NF-κB with SIRT1.Evogliptin tartrate significantly inhibits the TNF-α-mediated induction of ICAM-1 and VCAM-1 expression in a concentration-dependent manner (IC50 = 0.30 and 0.25 μM, respectively).
In vivo Evogliptin tartrate inhibits the formation of atherosclerotic lesions by reducing vasoinflammation and increases plaque stability.Evogliptin tartrate (37.5-150 mg/kg; p.o.; daily; for 12 weeks) reduces the high-fat diet-induced atherosclerotic plaque area in the ApoE?/? mouse model.
Synonyms DA-1229 tartrate
Molecular Weight 551.51
Formula C23H32F3N3O9
CAS No. 1222102-51-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Modulation of Sirt1/NF-κB interaction of evogliptin is attributed to inhibition of vascular inflammatory response leading to attenuation of atherosclerotic plaque formation. Biochem Pharmacol. 2019 Oct;168:452-464.

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Keywords

Evogliptin tartrate 1222102-51-3 Proteases/Proteasome DPP-4 DA1229 Tartrate Evogliptin Tartrate DA-1229 Tartrate DA 1229 Tartrate DA-1229 tartrate inhibitor inhibit

 

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