Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EC-17 (disodium salt), a folate receptor alpha (FRα) targeting contrast agent, exhibits fluorescent properties within the visible light spectrum, characterized by peak excitation and emission wavelengths of 470/520 nm, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 697.00 | |
10 mg | Inquiry | $ 1,190.00 | |
25 mg | Inquiry | $ 2,360.00 | |
50 mg | Inquiry | $ 3,770.00 |
Description | EC-17 (disodium salt), a folate receptor alpha (FRα) targeting contrast agent, exhibits fluorescent properties within the visible light spectrum, characterized by peak excitation and emission wavelengths of 470/520 nm, respectively. |
In vitro | EC-17 contains the fluorescein fluorochrome and has a spectral wavelength of 490–530?nm. EC-17 is synthesized by a folate (vitamin B9) and fluorescein isothiocyanate (FITC) conjugated through an ethylenediamine spacer to produce folate-FITC, with a molecular weight of 917?kDa. The signal-to-background ratio (SBR) of EC-17 for HeLa cells range from 0.97 to 7.32 depending on the molarity and concentration of cancer cells. |
In vivo | Fluorescence microscopy utilizing folate-FITC demonstrated a pronounced signal across all malignant tumors possessing FR-α, indicating a significant expression. In contrast, no signal was detected in malignant or benign lesions lacking FR-α. Furthermore, the average fluorescence intensity measured in animals administered with EC-17 was 42,234 ± 12,234 arbitrary units (au), underscoring the specificity of the response. |
Molecular Weight | 895.86 |
Formula | C42H36N10NaO10S |
CAS No. | 910661-33-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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EC-17 disodium salt 910661-33-5 Others EC-17 disodium EC 17 EC-17 EC17 EC17 disodium salt EC 17 disodium salt inhibitor inhibit