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Cenisertib

Catalog No. T14925 CAS 871357-89-0

Synonyms: AS-703569, R-763

Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well as kinase inhibitors of FER and its homolog. Cenisertib inhibits the growth of tumor mast cells (MCS) by inhibiting the activity of several different molecular targets. Cenisertib also inhibits tumor growth in pancreatic, breast, colon, ovarian and lung cancer and leukemia in xenograft models.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Cenisertib, CAS 871357-89-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 987.00
50 mg	6-8 weeks	$ 1,360.00
100 mg	6-8 weeks	$ 1,860.00
1 mL * 10 mM (in DMSO)	6-8 weeks	$ 365.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	AS-703569, R-763
Molecular Weight	451.54
Formula	C24H30FN7O
CAS No.	871357-89-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (553.66 mM), Sonication is recommended.

References and Literature

1. Peter B, et al. Drug-induced inhibition of phosphorylation of STAT5 overrides drug resistance in neoplastic mast cells. Leukemia. 2018 Apr;32(4):1016-1022. 2. McLaughlin J, et al. Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cenisertib 871357-89-0 Angiogenesis Cytoskeletal Signaling JAK/STAT signaling PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors Bcr-Abl STAT Akt R763 AS 703569 AS-703569 AS703569 R 763 R-763 inhibitor inhibit

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