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Anamorelin Fumarate

Catalog No. T10319L CAS 339539-92-3

Synonyms: ONO-7643 Fumarate, RC1291 Fumarate

Anamorelin Fumarate is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).

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Anamorelin Fumarate, CAS 339539-92-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Anamorelin Fumarate is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).
Targets&IC50	Ghrelin receptor:（EC50）0.74 nM , Ghrelin receptor:（ki）0.7 nM
In vitro	No significant antagonist activity is observed with Anamorelin at concentrations of up to 1,000 nM. In the binding experiments, Anamorelin binds to the ghrelin receptor with a binding affinity constant (Ki) of 0.70 nM. In the competition assay with radiolabeled ibutamoren (another ghrelin receptor agonist), Anamorelin is also found to bind with high affinity to the ghrelin receptor (IC50: 0.69 nM). In rat pituitary cells incubated with Anamorelin, there is a dose-dependent stimulatory effect on GH release and the potency (EC50) is 1.5 nM. Anamorelin is screened for activity against a set of over 100 receptors, ion channels, transporters, and enzymes. Anamorelin demonstrates binding to the tachykinin neurokinin 2 (NK2) site (IC50: 0.021 μM); however, a subsequent NK2 functional assay demonstrates no functional activity.
In vivo	In rats, oral administration of Anamorelin at doses of 3, 10, or 30 mg/kg once daily significantly enhanced food intake and body weight from Day 2 to Day 7 of treatment, compared to the vehicle control. The observed increases in food consumption and weight gain were dose-dependent and statistically significant across all dosage levels when compared to the control group. Additionally, a single oral dose of Anamorelin at 3, 10, or 30 mg/kg resulted in a dose-dependent elevation in plasma GH levels and GH AUC0-6h.

Synonyms	ONO-7643 Fumarate, RC1291 Fumarate
Molecular Weight	662.78
Formula	C35H46N6O7
CAS No.	339539-92-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5(4):329-37.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Anamorelin Fumarate 339539-92-3 Others ONO7643 Fumarate ONO-7643 Fumarate RC 1291 Fumarate RC-1291 Fumarate RC1291 Fumarate ONO 7643 Fumarate inhibitor inhibit

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