Powder: -20°C for 3 years | In solvent: -80°C for 1 year
A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | 5 days | $ 1,090.00 |
Description | A 83-01 sodium salt is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC 50 s of 12 nM, 45 nM and 7.5 nM against the ALK5, ALK4 and ALK7 induced transcription, respectively [1]. |
Targets&IC50 | ALK7 (cell-based assay):7.5 nM , ALK5 (cell-based assay):12 nM , ALK4 (cell-based assay):45 nM |
In vitro | A 83-01 sodium salt is a powerful inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, significantly reducing ALK-5-induced transcription with an IC50 of 12 nM in Mv1Lu cells. It also inhibits ALK4-TD and ALK7-TD induced transcription in R4-2 cells with IC50 values of 45 nM and 7.5 nM, respectively, while only mildly suppressing transcription induced by constitutively active ALK-6, ALK-2, ALK-3, and ALK-1. At concentrations ranging from 0.03-10 μM, A 83-01 effectively counteracts the growth-inhibitory effects of TGF-β, completely negating this effect at 3 μM. Furthermore, A 83-01 at 1-10 μM prevents TGF-β-induced Smad activation in HaCaT cells, and at 1 μM, it decreases TGF-β1-enhanced cell motility, adhesion, and invasion in HM-1 cells without affecting cell proliferation. |
In vivo | A 83-01, administered intraperitoneally (i.p.) at doses of 50, 150, and 500 μg/mouse, significantly enhances survival rates in mice without affecting their body weight or neurobehavioral functions [2]. At a dosage of 0.5 mg/kg, A 83-01 exhibits a pronounced antitumor effect in mice with M109 cells [3]. |
Molecular Weight | 444.51 |
Formula | C25H19N5NaS+ |
CAS No. | 2828431-89-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (224.97 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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A 83-01 sodium salt 2828431-89-4 Angiogenesis Tyrosine Kinase/Adaptors ALK A 83 01 sodium salt A 8301 sodium salt A 83-01 sodium inhibitor inhibit