Apoptosis Compound Library

Catalog No. L9000

Library Compound List Excel SDF

Apoptosis is a form of programmed cell death that occurs in multicellular organisms. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's lifecycle. Apoptosis leads to characteristic cell changes (morphology): the cell breaks apart into multiple vesicles called apoptotic bodies, which undergo phagocytosis. Apoptosis is regulated by both pro-apoptotic (such as Fas receptor and caspases) and anti-apoptotic (such as Bcl-2 and IAP) factors. Disordered apoptosis is implicated in a variety of human diseases. Inhibition of apoptosis can result in a number of cancers, autoimmune diseases, inflammatory diseases, and viral infections. Excessive apoptosis may also be a feature of some conditions such as autoimmune diseases, neurodegenerative diseases, and ischemia-associated injury. Consequently, considerable interest has arisen in therapeutic strategies for cancer, autoimmune diseases, and neurodegenerative diseases by modulating apoptosis pharmacologically.

TargetMol’s collection of 1796 apoptosis-related compounds, Apoptosis Compound Library, is divided accordingly with compounds designed for either pro- or anti-apoptosis purposes and can be used for research in cancer and neurodegenerative diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;
Targets include Bcl-2, Caspase, p53, TNF-alpha, and surviving, etc.;
Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Apoptosis (1016)

Autophagy (369)

Endogenous Metabolite (114)

Ferroptosis (100)

NF-κB (93)

Antibacterial (89)

TNF (85)

EGFR (75)

Caspase (66)

BCL (59)

Reactive Oxygen Species (55)

JAK (54)

COX (50)

STAT (50)

DNA/RNA Synthesis (49)

p38 MAPK (48)

CDK (48)

ERK (48)

VEGFR (47)

Raf (46)

PI3K (44)

Antibiotic (42)

FLT (38)

Mitophagy (37)

HDAC (37)

HIV Protease (36)

Src (36)

PDGFR (34)

Antifungal (34)

Akt (34)

Parasite (34)

MEK (33)

p53 (32)

c-Kit (31)

c-RET (30)

Microtubule Associated (30)

mTOR (29)

Influenza Virus (28)

IL Receptor (28)

JNK (28)

FGFR (27)

Epigenetic Reader Domain (26)

Antioxidant (26)

E1/E2/E3 Enzyme (26)

Dehydrogenase (25)

Bcr-Abl (23)

HSP (22)

AMPK (22)

Aurora Kinase (22)

PARP (21)

Ras (21)

PKC (21)

PPAR (20)

Topoisomerase (20)

Nucleoside Antimetabolite/Analog (19)

Proteasome (19)

Interleukin (19)

RIP kinase (18)

Tyrosine Kinases (18)

Mdm2 (18)

HER (17)

AChR (16)

Virus Protease (16)

Mitochondrial Metabolism (16)

Histone Methyltransferase (16)

Phosphatase (16)

PERK (16)

MAPK (15)

Serine/threonin kinase (15)

Sirtuin (15)

c-Met/HGFR (14)

P450 (14)

IκB/IKK (14)

ROS (14)

NO Synthase (13)

GSK-3 (13)

DNA Alkylator/Crosslinker (13)

MMP (13)

Potassium Channel (12)

RAAS (12)

IAP (12)

HSV (12)

Lipoxygenase (12)

Calcium Channel (12)

Estrogen Receptor/ERR (11)

Estrogen/progestogen Receptor (11)

c-Myc (11)

ATPase (11)

Tyrosinase (11)

Wnt/beta-catenin (11)

PKA (11)

TRP/TRPV Channel (11)

IGF-1R (10)

PD-1/PD-L1 (10)

PDE (10)

DNA-PK (10)

Dopamine Receptor (10)

FAK (10)

Gamma-secretase (9)

Beta Amyloid (9)

Pim (9)

Chk (9)

DUB (9)

Histamine Receptor (9)

Sodium Channel (9)

Syk (9)

TAM Receptor (9)

Retinoid Receptor (9)

Phospholipase (8)

Nrf2 (8)

SARS-CoV (8)

AChE (8)

TGF-beta/Smad (8)

PLK (8)

Trk receptor (8)

TLR (8)

5-HT Receptor (8)

Drug Metabolite (8)

c-Fms (8)

Fatty Acid Synthase (8)

DNA Alkylation (7)

NADPH (7)

Reverse Transcriptase (7)

Casein Kinase (7)

Adrenergic Receptor (7)

HIF/HIF Prolyl-Hydroxylase (7)

HBV (7)

GPR (7)

PDK (7)

HMG-CoA Reductase (7)

HIF (7)

HCV Protease (7)

P-gp (7)

Histone Acetyltransferase (6)

S6 Kinase (6)

Antifolate (6)

BTK (6)

Kinesin (6)

CaMK (6)

Cysteine Protease (6)

ALK (6)

Prostaglandin Receptor (6)

NOS (5)

GluR (5)

Glutathione Peroxidase (5)

MAO (5)

UGT (5)

Monoamine Oxidase (5)

ROCK (5)

S1P Receptor (5)

Anti-infection (5)

Rho (5)

Opioid Receptor (5)

Integrin (5)

DHFR (4)

Serine Protease (4)

ASK (4)

Aryl Hydrocarbon Receptor (4)

PTEN (4)

ROR (4)

ATM/ATR (4)

DPP-4 (4)

DNA Methyltransferase (4)

OXPHOS (4)

PAK (4)

MRP (4)

CSF-1R (4)

iGluR (4)

Antiviral (4)

Histone Demethylase (4)

MLK (4)

Telomerase (4)

GABA Receptor (4)

Transferase (4)

Proton pump (3)

IRE1 (3)

TOPK (3)

PAI-1 (3)

CRISPR/Cas9 (3)

Adenosine Receptor (3)

Pyroptosis (3)

IFNAR (3)

DNA (3)

Acyltransferase (3)

PGE Synthase (3)

Hexokinase (3)

GPX (3)

MNK (3)

Leukotriene Receptor (3)

STING (3)

FXR (3)

NADPH-oxidase (3)

NAMPT (3)

Glucocorticoid Receptor (3)

Glucokinase (3)

NOD-like Receptor (NLR) (3)

LTR (3)

Survivin (3)

Lipid (3)

Reductase (3)

Progesterone Receptor (2)

Antifection (2)

BACE (2)

BMI-1 (2)

Aromatase (2)

VDA (2)

VDAC (2)

cAMP (2)

Aminopeptidase (2)

Xanthine Oxidase (2)

Smo (2)

SGK (2)

Androgen Receptor (2)

YAP (2)

CRM1 (2)

Immunology/Inflammation related (2)

LRRK2 (2)

LPL Receptor (2)

Myosin (2)

Liver X Receptor (2)

FLAP (2)

NOD (2)

IRAK (2)

P2 Receptor (2)

P2X Receptor (2)

Free radical scavengers (2)

PAFR (2)

Hck (2)

Hedgehog/Smoothened (2)

PAD (2)

KSP (1)

Arginase (1)

lysosomal autophagy (1)

Stearoyl-CoA Desaturase (SCD) (1)

ACK (1)

Wee1 (1)

Hydrogenase (1)

Glutathione reductase (1)

Lipase (1)

Adenosine deaminase (1)

Guanylate cyclase (1)

Thrombin (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Tie-2 (1)

KLF (1)

GNRH Receptor (1)

Amino Acids and Derivatives (1)

Somatostatin (1)

transporter (1)

GTPase (1)

IDO (1)

AhR (1)

GST (1)

Sigma receptor (1)

Melatonin Receptor (1)

OCT (1)

cholecystokinin (1)

PKM (1)

Chloride channel (1)

CFTR (1)

CXCR (1)

p97 (1)

Dynamin (1)

Endothelin Receptor (1)

PYK2 (1)

Ephrin Receptor (1)

Carbonic Anhydrase (1)

RAR/RXR (1)

Epoxide Hydrolase (1)

FAAH (1)

MTH1 (1)

Fas/FasL (1)

NPC1L1 (1)

Beta-Secretase (1)

Norepinephrine (1)

NMDAR (1)

RSV (1)

Neurokinin receptor (1)

Neprilysin (1)

Na+/Ca2+ Exchanger (1)

FOXO1 (1)

SGLT (1)

PI4K (1)

SIK (1)

Hippo pathway (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty