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TargetMol | Compound Library

Fluorochemical Library

Catalog No. L5100

Fluorine atoms have a unique combination of electronic and physical properties. As such, when incorporated into active pharmaceutical ingredients (APIs), fluorine atoms often influence their protein binding affinity and lipophilicity but not the shape of the resulting fluorochemicals. Fluorination can thus significantly impact the bioavailability or metabolic stability of drug substances. The pivotal role that the element fluorine plays in modulating the properties of bioactive molecules is reflected by the growth of its presence in approved drugs, as evidenced by the fact that between 15% to 20% of all medicines and agrochemicals on the market contain at least one fluorine atom in their structure. As of 2009, the FDA had approved >140 fluorine-containing drugs, such as fluorouracil, Miglitol, Gemcitabine, Sofosbuvir, atorvastatin, fluoxetine, ciprofloxacin, etc. The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties. Nowadays, the application of specialty fluorochemicals in the pharmaceutical industry has been increasingly widespread. TargetMol’s fluorochemical library has become an effective tool for developing new anticancer drugs, anesthetics, antidepressants, antifungals, antiviral drugs, antibiotics, cholesterol lowering agents, and anti-inflammatory agents. In addition, in agricultural uses, the addition of fluorine to many agricultural herbicides, pesticides, and fungicides improves the potency and therefore reduces the required application rate of these substances.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L5100

Fluorochemical Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 2684 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • NMR and HPLC validated to ensure high purity and quality;
  • All compounds are in stock.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Composition

Apoptosis
Autophagy
5-HT Receptor
Antibacterial
VEGFR
EGFR
Antibiotic
Dehydrogenase
PI3K
DNA/RNA Synthesis
Dopamine Receptor
Raf
Antifungal
Sodium Channel
CDK
p38 MAPK
Potassium Channel
FLT
HIV Protease
c-Met/HGFR
TRP/TRPV Channel
PDGFR
GluR
COX
Parasite
Calcium Channel
PDE
c-Kit
Kras
Bcr-Abl
Androgen Receptor
Src
Glucocorticoid Receptor
Epigenetic Reader Domain
GPR
JAK
Prostaglandin Receptor
Histone Methyltransferase
GABA Receptor
HCV Protease
PARP
Phospholipase
MEK
AChR
Adrenergic Receptor
BTK
Aurora Kinase
FGFR
Nucleoside Antimetabolite/Analog
SARS-CoV
mTOR
HER
PPAR
Gamma-secretase
CCR
P450
MAPK
HBV
Topoisomerase
c-RET
TAM Receptor
ERK
HDAC
Microtubule Associated
Estrogen/progestogen Receptor
Histamine Receptor
iGluR
DUB
Antiviral
Trk receptor
ROR
Phosphatase
Wnt/beta-catenin
Akt
S6 Kinase
Proteasome
Reductase
GSK-3
Tyrosine Kinases
NMDAR
ALK
Casein Kinase
STAT
YAP
Virus Protease
Cysteine Protease
Caspase
Guanylate cyclase
IL Receptor
Influenza Virus
Ras
CFTR
Adenosine Receptor
PKC
ROCK
Glucagon Receptor
CXCR
Histone Acetyltransferase
IκB/IKK
NF-κB
PLK
Cannabinoid Receptor
Discoidin Domain Receptor (DDR)
S1P Receptor
Mdm2
Proton pump
LPL Receptor
CETP
Estrogen Receptor/ERR
MAO
E1/E2/E3 Enzyme
ROS
Isocitrate Dehydrogenase (IDH)
BCL
Epoxide Hydrolase
Indoleamine 2,3-Dioxygenase (IDO)
TGF-beta/Smad
HSP
STING
HIF
TNF
Neurokinin receptor
FAK
ROS Kinase
Ferroptosis
BACE
PERK
Mitophagy
Rho
Liver X Receptor
RIP kinase
P2X Receptor
DPP-4
Hedgehog/Smoothened
Lipoxygenase
transporter
Beta Amyloid
AMPK
Chloride channel
Serotonin Transporter
IDO
Opioid Receptor
FAAH
OX Receptor
Interleukin
Reverse Transcriptase
Hydroxylase
HMG-CoA Reductase
p53
DNA-PK
ADC Cytotoxin
P2Y Receptor
Lipase
Serine Protease
Aryl Hydrocarbon Receptor
DNA gyrase
Neuropeptide Y Receptor
Stearoyl-CoA Desaturase (SCD)
LRRK2
Ephrin Receptor
Nrf2
ATM/ATR
c-Fms
IRAK
HIF/HIF Prolyl-Hydroxylase
AhR
ATPase
Carbonic Anhydrase
Transferase
CRM1
Tie-2
GTPase
c-Myc
GNRH Receptor
PKA
Pim
Glucokinase
CSF-1R
GRK
Drug Metabolite
Mitochondrial Metabolism
Smo
Reactive Oxygen Species
Chk
Beta-Secretase
Acyltransferase
TLR
PI4K
Syk
Sigma receptor
Kinesin
Monoamine Oxidase
Melanin-concentrating Hormone Receptor (MCHR)
NOS
Integrin
DYRK
Serine/threonin kinase
IAP
GlyT
Fatty Acid Synthase
PAK
HSV
MMP
IGF-1R
Norepinephrine
P-gp
RSV
Retinoid Receptor
PDK
DNA Methyltransferase
Antioxidant
NADPH
Factor Xa
FXR
Leukotriene Receptor
LIM Kinase
Neurotensin Receptor
IRE1
Myosin
DNA Alkylation
Somatostatin
OXPHOS
PGE Synthase
PSMA
Sirtuin
ASK
Methionine Adenosyltransferase (MAT)
Endogenous Metabolite
GHSR
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NOD
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Monocarboxylate transporter
MALT
DprE1
IFNAR
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RAR/RXR 
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RAAS
JNK
Galectin
CaSR
MRP
NAMPT
PYK2
Glutaminase
SIK
Annexin A
Phosphorylase
Antifection
Integrase
Vasopressin Receptor
Xanthine Oxidase
ACK
KSP
cAMP
Telomerase
SGLT
MRGPR
Porcupine
CRFR
GPX
LPA Receptor
CGRP Receptor
SGK
NOD-like Receptor (NLR)
Thyroid hormone receptor(THR)
Adenylyl cyclase
PROTACs
NPC1L1
DHFR
NEDD8
Amino Acids and Derivatives
LTR
Na+/Ca2+ Exchanger
Glutathione Peroxidase
Progesterone Receptor
OCT
N-Acetylglucosaminyltransferase
VDAC
Hck
FOXO1
RANKL/RANK
Immunology/Inflammation related
Motilin Receptor
UGT
MTH1
LDL
AAK1 (AP2 associated kinase 1)
Monoamine Transporter
Anion Exchanger
Bombesin Receptor
Bradykinin Receptor
PTEN
CaMK
DNA
ATP Citrate Lyase
BCRP
OAT
Survivin
MNK
CD73
AIM2
GluCls
PAI-1
MELK
Acetyl-CoA Carboxylase
Protease
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Melanocortin Receptor
KLF
Aquaporin
RXFP receptor
Anti-infection
BMI-1
Tyrosinase
Thrombin
lysosomal autophagy
MLK
PD-1/PD-L1
NO Synthase
PKM