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SDH-IN-45
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Catalog No. T218086 Copy Product Info
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SDH-IN-45 is a targeted inhibitor of succinate dehydrogenase (BcSDH) and a mycelial growth inhibitor for Botrytis cinerea, with an IC50 of 5.97 μg/mL. It disrupts the mitochondrial electron transport chain component succinate dehydrogenase through a unique binding mode, thus regulating fungal energy metabolism. SDH-IN-45 induces morphological damage to Botrytis cinerea mycelia, causing structural collapse and shrinkage. This compound shows in vitro fungicidal activity against Botrytis cinerea and can be used in studies related to cucumber gray mold.
SDH-IN-45
Cas No. 3112883-32-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SDH-IN-45 is a targeted inhibitor of succinate dehydrogenase (BcSDH) and a mycelial growth inhibitor for Botrytis cinerea, with an IC50 of 5.97 μg/mL. It disrupts the mitochondrial electron transport chain component succinate dehydrogenase through a unique binding mode, thus regulating fungal energy metabolism. SDH-IN-45 induces morphological damage to Botrytis cinerea mycelia, causing structural collapse and shrinkage. This compound shows in vitro fungicidal activity against Botrytis cinerea and can be used in studies related to cucumber gray mold. |
| In vitro | SDH-IN-45 (compound 4i) effectively inhibits the mycelial growth of various plant pathogenic fungi. At a concentration of 50 μg/mL, it achieves a 75.0% inhibition rate against Botrytis cinerea. SDH-IN-45 inhibits the succinate dehydrogenase of Botrytis cinerea with an IC50 of 5.97 μg/mL. At 7 μg/mL during the mycelial growth phase, SDH-IN-45 causes morphological damage to the mycelia of Botrytis cinerea, including mycelial collapse and shrinkage. The compound has an EC50 of 6.64 μg/mL for inhibiting the mycelial growth of Botrytis cinerea. |
| In vivo | SDH-IN-45 (compound 4i) (200 μg/mL) exhibits relatively low in vivo antifungal activity against a variety of fungal pathogens in crops. |
| Molecular Weight | 387.35 |
| Formula | C21H16F3NO3 |
| Cas No. | 3112883-32-3 |
| Smiles | O=C(NOCC=1C=CC=CC1OC=2C=CC=CC2)C=3C=CC=CC3C(F)(F)F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: SDH-IN-45 in vivo | SDH-IN-45 in vitro | SDH-IN-45 formula | SDH-IN-45 molecular weight
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