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PJ17
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Catalog No. T218884 Copy Product Info
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PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. In primary cerebellar granule neuron cultures, PJ17 shows no significant neurotoxicity. It can serve as a template for multi-target drug design and is useful in Alzheimer's disease research.
PJ17
Cas No. 2248983-31-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. In primary cerebellar granule neuron cultures, PJ17 shows no significant neurotoxicity. It can serve as a template for multi-target drug design and is useful in Alzheimer's disease research. |
| Targets & IC50 | AChE:8.84 μM |
| In vitro | PJ17 (30-100 μM) effectively inhibits acetylcholinesterase (AChE) with an IC50 of 8.84 μM. At 10 μM, PJ17 strongly inhibits human recombinant glycogen synthase kinase-3 beta (GSK-3β) with an IC50 of 4.19 μM, achieving an inhibition rate of 85.95%. At concentrations up to 50 μM, PJ17 (2.5-50 μM; 24-48 h) does not induce neurotoxicity in primary cerebellar granule neuron (CGN) cultures and can enhance cell viability at 10-50 μM. However, with pre-treatment concentrations of 2.5-50 μM for 1-24 hours, PJ17 does not exhibit significant neuroprotective activity against Rotenone-induced toxicity in primary CGN cultures at concentrations up to 50 μM. PJ17 shows no significant inhibitory effects on rat monoamine oxidase-A (MAO-A), MAO-B, or human recombinant beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1). |
| Molecular Weight | 300.29 |
| Formula | C15H13FN4O2 |
| Cas No. | 2248983-31-3 |
| Smiles | O=C(NC=1C=CN=CC1F)C=2C=CN=C(C2)NC(=O)C3CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: PJ17 in vitro | PJ17 formula | PJ17 molecular weight
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