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(E,E)-Farnesyl Pyrophosphate ammonium salt

Name: (E,E)-Farnesyl Pyrophosphate ammonium salt
Brand: TargetMol
SKU: T37775
Price: 627 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37775Cas No. 116057-57-9

Alias (E,E)-FPP ammonium, (E,E)-Farnesyl pyrophosphate ammonium, (E,E)-Farnesyl diphosphate ammonium

Farnesyl Pyrophosphate ammonium (Farnesyl diphosphate ammonium) is a metabolic intermediate of the MVA pathway that acts as a newly identified danger signal to trigger acute cell death and induce neuronal loss in stroke.

(E,E)-Farnesyl Pyrophosphate ammonium salt

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Purity: 99.72%

Catalog No. T37775Alias (E,E)-FPP ammonium, (E,E)-Farnesyl pyrophosphate ammonium, (E,E)-Farnesyl diphosphate ammoniumCas No. 116057-57-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$627	-	In Stock
1 mL x 2.31 mM (in MeOH/10 mM NH4OH(70:30))	Inquiry	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.72%

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Product Introduction

Bioactivity

Description	Farnesyl Pyrophosphate ammonium (Farnesyl diphosphate ammonium) is a metabolic intermediate of the MVA pathway that acts as a newly identified danger signal to trigger acute cell death and induce neuronal loss in stroke.
In vitro	METHODS: B cell line A20 cells, mouse mastocytoma cell line P815, Jurkat T cell line, primary splenocytes, and primary thymocytes were treated with farnesyl pyrophosphate (15 μg/mL and 30 μg/mL) and the nuclear and plasma membranes were stained to capture morphological changes after FPP treatment by confocal microscopy. RESULTS: Within 5 minutes of adding farnesyl pyrophosphate, P815 cells began to show cytoplasmic swelling that increased over time until the plasma membrane eventually ruptured. [1]
Synonyms	(E,E)-FPP ammonium, (E,E)-Farnesyl pyrophosphate ammonium, (E,E)-Farnesyl diphosphate ammonium

Chemical Properties

Molecular Weight	433.42
Formula	C₁₅H₃₇N₃O₇P₂
Cas No.	116057-57-9
Smiles	CC(C)=CCC/C(C)=C/CC/C(C)=C/COP(=O)([O-])OP(=O)([O-])[O-].[NH4+].[NH4+].[NH4+]

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (230.72 mM), Sonication is recommended.

Methanol:NH4OH (70:30): 1 mg/mL (2.31 mM), Sonication is recommended.

Solution Preparation Table

Methanol:NH4OH (70:30)/H2O

	1mg	5mg	10mg	50mg
1 mM	2.3072 mL	11.5362 mL	23.0723 mL	115.3615 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4614 mL	2.3072 mL	4.6145 mL	23.0723 mL
10 mM	0.2307 mL	1.1536 mL	2.3072 mL	11.5362 mL
20 mM	0.1154 mL	0.5768 mL	1.1536 mL	5.7681 mL
50 mM	0.0461 mL	0.2307 mL	0.4614 mL	2.3072 mL
100 mM	0.0231 mL	0.1154 mL	0.2307 mL	1.1536 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

(E,E)-Farnesyl Pyrophosphate (ammonium salt)(E,E)-Farnesyl Pyrophosphate

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