Coumoxystrobin

Coumoxystrobin is a methoxyacrylate strobilurin fungicide that exhibits antifungal (fungal) activity. It inhibits the hyphal growth of rice blast fungus, enhances cell membrane permeability, and reduces respiration. In ex vivo barley leaves, it provides protective activity against rice blast fungus. Coumoxystrobin also decreases ATP activity in Chlorella vulgaris, leading to algal death. It is applicable in research related to rice blast disease.

Coumoxystrobin effectively inhibits the hyphal growth of 100 Magnaporthe oryzae strains with an average EC50 value of 0.0163 μg/mL when used at concentrations of 0.0025-0.08 μg/mL over 7 days. At 0.1 μg/mL for 3 days, it induces morphological aberrations in hyphal growth of Magnaporthe oryzae strains L-14, L-15, and YE-9, causing twisted hyphal tips and increased apical branching. Additionally, at a concentration of 0.1 μg/mL for 48 hours, Coumoxystrobin disrupts cell membrane permeability in strains L-15 and YE-9, leading to increased electrolyte leakage. It also significantly decreases the respiration rate of these strains at 0.1 μg/mL. The compound exhibits dose-dependent protective activity against the Magnaporthe oryzae strain YE-9 on detached barley leaves at concentrations of 1-4 μg/mL. Coumoxystrobin shows acute toxicity to Chlorella vulgaris with an EC50 of 1.62 mg/L and reduces cell yield by 97.8% at a concentration of 4.23 mg/L after 96 hours. Furthermore, it inhibits the mitochondrial complex III activity and decreases ATP survival rate in Chlorella vulgaris at concentrations of 0.15-1.08 mg/L over 24-96 hours.