Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 885.00 | |
50 mg | 8-10 weeks | $ 1,150.00 | |
100 mg | 8-10 weeks | $ 1,950.00 |
Description | UNC10217938A is a 3-deazapteridine analog, has strong oligonucleotide enhancing effects. |
In vitro | When UNC10217938A is used in the range of 5-25 μM, it can significantly enhance the induction of luciferase in HelaLuc705 cells, and it is more effective and more effective than Retro-1. Compared to a separate splice switch oligonucleotide (SSO), UNC10217938A provids a 60-fold enhancement at 10 μM and 220-fold at 20 μM, in contrast to a 11-fold enhancement for 100 μM Retro-1. UNC10217938A can substantially enhance effects of receptor targeted oligonucleotide conjugates. UNC10217938A can also enhance the effect of uncharged morpholino oligonucleotides and negatively charged oligonucleotides . Exposure of cells to UNC10217938A caused a significant reduction in the colocalization of TAMRA-oligonucleotides with the late ribosomal marker Rab7, but had little effect on the colocalization with the lysosomal marker LAMP-1. UNC10217938A causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation. |
Molecular Weight | 456.54 |
Formula | C26H28N6O2 |
CAS No. | 1347749-97-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UNC10217938A 1347749-97-6 Others UNC-10217938A inhibitor inhibit