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PMPA sodium

Catalog No. T25968 CAS 373645-42-2

Synonyms: PMPA sodium salt, PMPA tetrasodium salt, PMPA Na

PMPA sodium is a potent and selective glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase) inhibitor.

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PMPA sodium, CAS 373645-42-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

PMPA sodium is a potent and selective glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase) inhibitor.

Synonyms	PMPA sodium salt, PMPA tetrasodium salt, PMPA Na
Molecular Weight	318.08
Formula	C6H11Na4O7P
CAS No.	373645-42-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Rais R, Jiang W, Zhai H, Wozniak KM, Stathis M, Hollinger KR, Thomas AG, Rojas C, Vornov JJ, Marohn M, Li X, Slusher BS. FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities. JCI Insight. 2016 Aug 4;1(12). pii: e88634. PubMed PMID: 27536732; PubMed Central PMCID: PMC4985244. 2. Solínová V, Kasicka V, Sázelová P, Holý A. Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector. Electrophoresis. 2009 Jun;30(12):2245-54. doi: 10.1002/elps.200800790. PubMed PMID: 19544492. 3. Saxena BB, Han YA, Fu D, Rathnam P, Singh M, Laurence J, Lerner S. Sustained release of microbicides by newly engineered vaginal rings. AIDS. 2009 May 15;23(8):917-22. doi: 10.1097/QAD.0b013e32832af57c. PubMed PMID: 19381077. 4. Richardson DD, Caruso JA. Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection. Anal Bioanal Chem. 2007 Jun;388(4):809-23. Epub 2007 Mar 14. PubMed PMID: 17356819.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PMPA sodium 373645-42-2 PMPA sodium salt PMPA tetrasodium salt PMPA PMPA tetrasodium PMPA Na inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.