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N-(4-methoxyphenyl)prop-2-enamide

Name: N-(4-methoxyphenyl)prop-2-enamide
Brand: TargetMol
SKU: T50041
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50041Cas No. 7766-37-2

Alias N-(4-Methoxyphenyl)acrylamide

N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) is an acrylamide analog used as a molecular structural unit. It inhibits the enzyme acetylcholinesterase, increasing acetylcholine levels in the synaptic gap. It can also inhibit the breakdown of dopamine, leading to increased dopamine levels in the brain.

N-(4-methoxyphenyl)prop-2-enamide

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Purity: 99.54%

Catalog No. T50041Alias N-(4-Methoxyphenyl)acrylamideCas No. 7766-37-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$89	In Stock	In Stock
25 mg	$152	In Stock	In Stock
50 mg	$229	In Stock	In Stock
100 mg	$343	In Stock	In Stock
200 mg	$488	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.54%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

N-(4-methoxyphenyl)prop-2-enamide AI Summary

N-(4-methoxyphenyl)prop-2-enamide inhibits human recombinant tissue transglutaminase 2 (TG2) with an IC50 value of 58000.0 nM as measured by a fluorescent transamidation assay. It has a half-life of 8.733 hours in phosphate buffer at pH 7.4 and a concentration of 50 µM in the presence of glutathione, as determined by LC-MS analysis. The compound displays bioactivity related to intrinsic clearance with a rate of 10.72 µL/min/(10^6 cells) in human hepatocytes and 42.66 µL/min/(10^6 cells) in rat hepatocytes. Additionally, it has a logD7.4 value of 1.68, indicating its distribution in an octan-1-ol/water system at pH 7.4. Furthermore, N-(4-methoxyphenyl)prop-2-enamide inhibits various enzymes and viruses, including West Nile virus NS2B-NS3 protease, Dengue virus serotype 2 NS2B-NS3 protease, and bovine thrombin, among others, with inhibition levels below 15.0%. It shows low reactivity with glutathione (GSH), forming adducts slowly, with an activity range from less than 0.1 L/mol/s up to less than 5.0% over various time frames. Its covalent reactive group exhibits a pseudo-first-order reaction rate constant (K) of 2.6 x 10^-3/min at 37°C, along with a reaction half-life with GSH of 4.5 hours at pH 7.4. Additionally, the compound shows thiol reactivity in PBS/DMSO buffer with a pseudo-first-order rate constant for adduct formation at K = 3.9 x 10^-5/s..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-(4-methoxyphenyl)prop-2-enamide (N-(4-Methoxyphenyl)acrylamide) is an acrylamide analog used as a molecular structural unit. It inhibits the enzyme acetylcholinesterase, increasing acetylcholine levels in the synaptic gap. It can also inhibit the breakdown of dopamine, leading to increased dopamine levels in the brain.
Synonyms	N-(4-Methoxyphenyl)acrylamide

Chemical Properties

Molecular Weight	177.2
Formula	C₁₀H₁₁NO₂
Cas No.	7766-37-2
Smiles	COC1=CC=C(NC(=O)C=C)C=C1
Relative Density.	1.12g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (310.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6433 mL	28.2167 mL	56.4334 mL	282.1670 mL
5 mM	1.1287 mL	5.6433 mL	11.2867 mL	56.4334 mL
10 mM	0.5643 mL	2.8217 mL	5.6433 mL	28.2167 mL
20 mM	0.2822 mL	1.4108 mL	2.8217 mL	14.1084 mL
50 mM	0.1129 mL	0.5643 mL	1.1287 mL	5.6433 mL
100 mM	0.0564 mL	0.2822 mL	0.5643 mL	2.8217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

N-(4-methoxyphenyl)prop-2-enamideN(4methoxyphenyl)prop2enamideN (4 methoxyphenyl)prop 2 enamide

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