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Motixafortide

Catalog No. T14665 CAS 664334-36-5

Synonyms: BL-8040, BKT140 (4-fluorobenzoyl), TF14016

Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).

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Motixafortide, CAS 664334-36-5

Pack Size	Availability	Price/USD	Quantity
25 mg	5 days	$ 747.00
50 mg	5 days	$ 1,190.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
Targets&IC50	CXCR4:1 nM
In vitro	Motixafortide (BKT140) exhibits selective toxicity against AmL and MM cells by specifically inducing CXCR4-dependent and apoptotic cell death in these leukemia and multiple myeloma (MM) cell types. Additionally, treatment with Motixafortide (BKT140) counteracts the IL-6 dependent proliferation and survival observed in ARH77 MM cells.
In vivo	Treatment with Motixafortide (BKT140) results in reduced size and weight of tumors in animals, alongside increased necrotic areas and elevated apoptotic scores[2]. Additionally, subcutaneous administration of Motixafortide (BKT140) markedly diminishes the growth of human acute myeloid leukemia and multiple myeloma xenografts in a dose-dependent fashion.

Synonyms	BL-8040, BKT140 (4-fluorobenzoyl), TF14016
Molecular Weight	2159.52
Formula	C97H144FN33O19S2
CAS No.	664334-36-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36 mg/mL (16.67 mM)

References and Literature

1. Peled A, et al. The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cellsin patients with multiple myeloma. Clin Cancer Res. 2014 Jan 15;20(2):469-79. 2. Beider K, et al. CXCR4 antagonist 4F-benzoyl-TN14003 inhibits leukemia and multiple myeloma tumor growth. Exp Hematol. 2011 Mar;39(3):282-92.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Motixafortide 664334-36-5 Autophagy GPCR/G Protein Immunology/Inflammation CXCR BL8040 BL-8040 BL 8040 4-fluorobenzoyl TF-14016 TF 14016 BKT 140 BKT140 (4-fluorobenzoyl) TF14016 BKT140 BKT-140 inhibitor inhibit

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