Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMG-11 inhibits both TLR2/1 and TLR2/6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses). MMG-11 is an effective and selective human TLR2 antagonist with low cytotoxicity.
Description | MMG-11 inhibits both TLR2/1 and TLR2/6 signaling (IC50s: 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses). MMG-11 is an effective and selective human TLR2 antagonist with low cytotoxicity. |
In vitro | MMG-11 (0.01-100?μM) shows no cytotoxic effects up to 100?μM in peripheral blood mononuclear cells (PBMCs). MMG-11 neither displays cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β, or TNF . |
Molecular Weight | 306.27 |
Formula | C15H14O7 |
CAS No. | 313254-94-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MMG-11 313254-94-3 Others MMG11 MMG 11 inhibitor inhibit