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Camobucol

Catalog No. T14861 CAS 216167-92-9

Synonyms: AGIX 4207

Camobucol is an orally active, anti-inflammatory compound. It also is a phenolic antioxidant with antirheumatic properties.

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Camobucol, CAS 216167-92-9

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Camobucol is an orally active, anti-inflammatory compound. It also is a phenolic antioxidant with antirheumatic properties.

In vitro

Camobucol demonstrates strong antioxidant properties, effectively combating lipid peroxides in vitro and showing improved absorption by cells. It also selectively suppresses levels of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 induced by tumor necrosis factor (TNF)-α, while minimally affecting E-selectin and not altering intracellular adhesion molecule-1 expression in endothelial cells. Moreover, Camobucol does not interfere with the TNF-α-driven relocation of NF-κB into the nucleus. It further reduces cytokine-stimulated production of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 in endothelial cells and human fibroblast-like synoviocytes, and curtails the release of TNF-α, IL-1β, and IL-6 after lipopolysaccharide exposure in human peripheral blood mononuclear cells.

Synonyms	AGIX 4207
Molecular Weight	574.88
Formula	C33H50O4S2
CAS No.	216167-92-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kunsch C, et al. AGIX-4207 [2-[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis(1,1-dimethylethyl)phenoxy]acetic acid], a novel antioxidant and anti-inflammatory compound: cellular and biochemical characterization of antioxidant activity and inhibition of redox-sensitive inflammatory gene expression. J Pharmacol Exp Ther. 2005 May;313(2):492-501. Epub 2005 Feb 8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Camobucol 216167-92-9 Others AGIX 4207 AGIX-4207 AGIX4207 inhibitor inhibit

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