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Caldaret

Catalog No. T14857 CAS 133804-44-1

Synonyms: MCC-135

Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.

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Caldaret, CAS 133804-44-1

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	$ 521.00
25 mg	6-8 weeks	$ 1,230.00
50 mg	6-8 weeks	$ 1,610.00
100 mg	6-8 weeks	$ 1,990.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.
In vitro	Caldaret resume Ca2+-ATPase activity of the sarcoplasmic reticulum isolated from the myocardium acutely exposed to ischemia and reperfusion in vitro [2].
In vivo	Caldaret (MCC-135) has beneficial effects in heart failure. In diabetic rats, Caldaret decreases TR80 significantly without a significant effect on developed tension (DT). Caldaret has minimal effects on SR Ca2+ uptake in normal rats, which is observed as increased SR Ca2+ uptake at uptake time of 20 and 30 s at the highest concentration of 10 μM. In diabetic rats, Caldaret increases SR Ca2+ uptake all over the range of uptake time. Both the initial rate of SR Ca2+ uptake and the amount of Ca2+ accumulated in the SR with longer uptake time are increased by Caldaret [2]. Caldaret limits the infarct size of the reperfused canine heart. The amelioration of intracellular Ca2+ handling dysfunction achieved by Caldaret leads to cardioprotective effects against reperfusion injury following prolonged ischemia [1].

Synonyms	MCC-135
Molecular Weight	256.32
Formula	C11H16N2O3S
CAS No.	133804-44-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kawasumi H, et al. Caldaret, an intracellular Ca2+ handling modulator, limits infarct size of reperfused canine heart. J Pharmacol Sci. 2007 Feb;103(2):222-33. 2. Satoh N, et al. Lusitropic effect of MCC-135 is associated with improvement of sarcoplasmic reticulum function in ventricular muscles of rats with diabetic cardiomyopathy. J Pharmacol Exp Ther. 2001 Sep;298(3):1161-6.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Caldaret 133804-44-1 Others MCC 135 MCC-135 MCC135 inhibitor inhibit

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