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BI-1230

Catalog No. T14555 CAS 849022-32-8

BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between other serine/cysteine proteases. Additionally, BI-1230 exhibits favorable pharmacokinetic (PK) properties[1].

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BI-1230, CAS 849022-32-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	BI-1230 is a potent inhibitor of HCV NS3 protease, exhibiting efficacy in the low nanomolar range, and notably suppresses viral replication. This compound demonstrates high selectivity, distinguishing effectively between other serine/cysteine proteases. Additionally, BI-1230 exhibits favorable pharmacokinetic (PK) properties[1].
Targets&IC50	HCV NS3 protease:6.7 nM
In vitro	BI-1230 demonstrates potent activity in biochemical and cellular assays. With a 60-minute incubation, it exhibits an IC50 value of 6.7 nM in an enzymatic assay[1]. Over 72 hours, BI-1230 shows EC50 values of 4.6 nM and <1.8 nM in a cell-based HCVPV RNA replication luciferase reporter assay with genotype backgrounds 1a and 1b, respectively, in Huh7 cells.
In vivo	BI-1230 (intravenous?injection; 2 mg/kg) shows good PK activity in rat: CL: 15 ml/min/kg, Mean residence time after iv dose: 2.3 hours, Vss: 2.05 L/kg[1]. BI-1230 (oral administation; 5 mg/kg) shows good PK activity in rat: T1/2: 2.1 hours; Tmax: 1.8 nM; Cmax: 405 nM; AUC0-inf: 2550 nM*h; F: 42%.

Molecular Weight	816.96
Formula	C42H52N6O9S
CAS No.	849022-32-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BI-1230 849022-32-8 Microbiology/Virology Proteases/Proteasome HCV Protease BI1230 BI 1230 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.