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Afeletecan free base

Catalog No. T23654 CAS 215604-75-4

Synonyms: BAY 56-3722, BAY56-3722, BAY-563722, Afeletecan

Afeletecan is a water-soluble camptothecin derivative. Afeletecan stabilizes the topoisomerase I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex. Both the initial cleavage reaction and religation steps are inhibited and subsequent collision of the replication fork with the cleaved strand of DNA results in inhibition of DNA replication, double-strand DNA breakage, and triggering of apoptosis.

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Afeletecan free base, CAS 215604-75-4

Pack Size	Availability	Price/USD	Quantity
25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	BAY 56-3722, BAY56-3722, BAY-563722, Afeletecan
Molecular Weight	895.98
Formula	C45H49N7O11S
CAS No.	215604-75-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506. PubMed PMID: 12949633. 2. Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. March 2003. Methods Find Exp Clin Pharmacol. 2003 Mar;25(2):145-68. PubMed PMID: 12731460.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Afeletecan free base 215604-75-4 BAY 56-3722 BAY56-3722 BAY563722 BAY-563722 BAY 563722 Afeletecan inhibitor inhibit

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