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ACHN-975 TFA

ACHN-975 TFA
ACHN-975 TFA is a selective LpxC inhibitor with subnanomolar inhibitory activity against a wide range of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
Catalog No. T10236Cas No. 1410809-37-8
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ACHN-975 TFA

Catalog No. T10236Cas No. 1410809-37-8
ACHN-975 TFA is a selective LpxC inhibitor with subnanomolar inhibitory activity against a wide range of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
25 mg$1,10010-14 weeks
50 mg$1,43010-14 weeks
100 mg$2,17010-14 weeks
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Product Introduction

Bioactivity
Description
ACHN-975 TFA is a selective LpxC inhibitor with subnanomolar inhibitory activity against a wide range of gram-negative bacteria, exhibiting low MIC values (≤1 μg/mL).
Targets&IC50
LpxC:
In vitro
ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively [1].ACHN-975 is potently against the P. aeruginosa isolates tested, inhibiting 100% of the isolates at a MIC of ≤2?μg/ml. It against Pseudomonas aeruginosa with an MIC50 and MIC90 of 0.06 and 0.25?μg/ml, respectively. ACHN-975 is against six P. aeruginosa isolates, it against P. aeruginosa APAE1064, APAE1232, and APAE1064 isolates with MIC values of 0.12, 0.06, and 0.06 ?μg/ml, respectively [2].
In vivo
ACHN-975 TFA (i.p.; 5-30?mg/kg; single dose) leads to a steady reduction in bacterial titers in the first 4?h following treatment for all dosing groups. The sampling shows that the level of free drug in this model drops below the ACHN-975 MIC for this isolate (0.25?μg/ml) by 2?h after treatment with the 10 mg/kg dose and by 4?h after treatment with the 30 mg/kg dose [2].
Animal Research
Animal Model: Neutropenic mouse thigh model with P. aeruginosa ATCC 27853. Dosage: 5-30 mg/kg. Administration: i.p.; single dose [2]
Chemical Properties
Molecular Weight483.4377
FormulaC22H24F3N3O6
Cas No.1410809-37-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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