Powder: -20°C for 3 years | In solvent: -80°C for 1 year
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 155.00 | |
1 mg | 35 days | $ 243.00 | |
5 mg | 35 days | $ 748.00 |
Description | 4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis. |
Molecular Weight | 352.295 |
Formula | C16H16O9 |
CAS No. | 66966-09-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL
DMSO: 5 mg/mL
DMF: 20 mg/mL
PBS (pH 7.2): 2 mg/mL
You can also refer to dose conversion for different animals. More
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4-Methylumbelliferyl-α-L-Iduronide (free acid) 66966-09-4 4MethylumbelliferylαLIduronide (free acid) 4 Methylumbelliferyl α L Iduronide (free acid) 4-Methylumbelliferyl-alpha-L-Iduronide 4-Methylumbelliferyl-a-L-Iduronide free acid 4-Methylumbelliferyl-α-L-Iduronide inhibitor inhibit