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4-Chloroloratadine

Catalog No. T20815 CAS 165739-83-3

Synonyms: 4-Chloro loratadine, Loratadine specified impurity C

4-Chloroloratadine is an impurity of Loratadine, a nonsedating-type histamine H1-receptor.

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4-Chloroloratadine, CAS 165739-83-3

Pack Size	Availability	Price/USD	Quantity
1 mg	Inquiry	$ 376.00
100 mg	Inquiry	$ 1,949.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

4-Chloroloratadine is an impurity of Loratadine, a nonsedating-type histamine H1-receptor.

Synonyms	4-Chloro loratadine, Loratadine specified impurity C
Molecular Weight	417.33
Formula	C22H22Cl2N2O2
CAS No.	165739-83-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Abd el-HS, Colyer CL, Hassan WS, Shalaby A. Utility of 4-chloro-7-nitrobenzofurazan (NBD-CI) for the Spectrophotometric and spectrofluorometric determination of several antihistamine and antihypertensive drugs. J AOAC Int. 2013 Sep-Oct;96(5):968-75. PubMed PMID: 24282933. 2. Parkinson A, Clement RP, Casciano CN, Cayen MN. Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice. Biochem Pharmacol. 1992 May 28;43(10):2169-80. PubMed PMID: 1534660. 3. Reddy KV, Babu JM, Kumar YR, Reddy SV, Kumar MK, Eswaraiah S, Reddy KR, Reddy MS, Bhaskar BV, Dubey PK, Vyas K. Impurity profile study of loratadine. J Pharm Biomed Anal. 2003 Apr 24;32(1):29-39. PubMed PMID: 12852446. 4. Zhong D, Blume H. [HPLC-determination of loratadine and its active metabolite descarboethoxyloratadine in human plasma]. Pharmazie. 1994 Oct;49(10):736-9. German. PubMed PMID: 7816900.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

4-Chloroloratadine 165739-83-3 4Chloroloratadine 4-Chloro loratadine 4 Chloroloratadine Loratadine specified impurity C inhibitor inhibit

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