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(S)-Trolox

Catalog No. T12816   CAS 53174-06-4

(S)-Trolox, an analogue of vitamin E, substitutes the phytyl chain with a carboxyl group. This compound serves as a model substance in structural studies and as a standard for assessing antioxidant activity. Moreover, (S)-Trolox exhibits potent and specific neuroprotective and antioxidant properties.

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(S)-Trolox Chemical Structure
(S)-Trolox, CAS 53174-06-4
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Biological Description
Chemical Properties
Storage & Solubility Information
Description (S)-Trolox, an analogue of vitamin E, substitutes the phytyl chain with a carboxyl group. This compound serves as a model substance in structural studies and as a standard for assessing antioxidant activity. Moreover, (S)-Trolox exhibits potent and specific neuroprotective and antioxidant properties.
In vitro In the absence of MK-801, (S)-Trolox displays marginal neuroprotective effects. In the presence of MK-801 (10 μM), the neuroprotective efficacy of (S)-Trolox is greatly enhanced, giving rise to a recovery in MTT-reductase activity equivalent to 80–100% of control cultures. (S)-Trolox displays EC50 of 78 μM. The fluorescence increase in IAA-stimulated DCFH-DA-loaded cultures is inhibited in a dose-dependent manner by the antioxidants (S)-Trolox (IC50 of 97 μM). The antioxidant (S)-Trolox demonstrate apotent and specific neuroprotective action in an in vitro model of neurodegeneration induced by inhibition of the glycolytic enzyme GAPDH[1].
Molecular Weight 250.29
Formula C14H18O4
CAS No. 53174-06-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Malcolm CS, et al. Characterization of iodoacetate-mediated neurotoxicity in vitro using primary cultures of rat cerebellar granule cells. Free Radic Biol Med. 2000 Jan 1;28(1):102-7. 2. Górecki M, et al. Chromane helicity rule--scope and challenges based on an ECD study of various trolox derivatives. Org Biomol Chem. 2014 Apr 14;12(14):2235-54.

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Keywords

(S)-Trolox 53174-06-4 Others (S) Trolox Trolox (S)Trolox inhibitor inhibit

 

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