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(±)8(9)-DiHET

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Catalog No. T37227Cas No. 192461-96-4

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.

(±)8(9)-DiHET

(±)8(9)-DiHET

😃Good
Catalog No. T37227Cas No. 192461-96-4
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μg$36635 days35 days
50 μg$68835 days35 days
100 μg$1,30035 days35 days
250 μg$2,88035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity. The 8(S),9(R)-EET isomer is metabolized by platelet COX to form 8(S),9(R),11(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor.
Chemical Properties
Molecular Weight338.488
FormulaC20H34O4
Cas No.192461-96-4
Relative Density.1.025 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
PBS (pH 7.2): 1 mg/mL (2.95 mM), Sonication is recommended.
Ethanol: 50 mg/mL (147.72 mM), Sonication is recommended.
DMSO: 50 mg/mL (147.72 mM), Sonication is recommended.
DMF: 50 mg/mL (147.72 mM), Sonication is recommended.
Solution Preparation Table
PBS (pH 7.2)/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.9543 mL14.7716 mL29.5431 mL147.7157 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
5 mM0.5909 mL2.9543 mL5.9086 mL29.5431 mL
10 mM0.2954 mL1.4772 mL2.9543 mL14.7716 mL
20 mM0.1477 mL0.7386 mL1.4772 mL7.3858 mL
50 mM0.0591 mL0.2954 mL0.5909 mL2.9543 mL
100 mM0.0295 mL0.1477 mL0.2954 mL1.4772 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

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Keywords

(±)8(9)DiHET(±)8(9) DiHET8(9)-DiHET
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