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(2R)-Octyl-α-hydroxyglutarate (Synonyms: (2R)-Octyl-2-HG)

Name: (2R)-Octyl-α-hydroxyglutarate
Brand: TargetMol
SKU: T19611
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T19611 Copy Product Info

Purity: 97%

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(2R)-Octyl-α-hydroxyglutarate is a modified derivative of the D-isomer of 2-hydroxyglutarate. (2R)-Octyl-α-hydroxyglutarate can improve adenine-induced arterial calcification in rats and inhibit pancreatic tissue damage, making it suitable for research on vascular calcification (VC) and acute pancreatitis.

(2R)-Octyl-α-hydroxyglutarate

Copy Product Info

🥰Excellent

Catalog No. T19611

Synonyms (2R)-Octyl-2-HG

Cas No. 1391194-67-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$52	-	In Stock
5 mg	$123	-	In Stock
10 mg	$197	-	In Stock
25 mg	$382	-	In Stock
50 mg	$569	-	In Stock
100 mg	$816	-	In Stock
1 mL x 10 mM (in DMSO)	$133	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97%

Appearance:Solid

Color:White

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COA HNMR

Product Introduction

Bioactivity

Description	(2R)-Octyl-α-hydroxyglutarate is a modified derivative of the D-isomer of 2-hydroxyglutarate. (2R)-Octyl-α-hydroxyglutarate can improve adenine-induced arterial calcification in rats and inhibit pancreatic tissue damage, making it suitable for research on vascular calcification (VC) and acute pancreatitis.
In vitro	Methods: IDH1 wild-type (IDH1-WT) HeLa cells were treated with (2R)-Octyl-α-hydroxyglutarate. Results: This compound dose-dependently increased the number of double-strand breaks (DSBs) in cells at the logarithmic growth phase, and is commonly used to investigate the effect of D-2-hydroxyglutarate on mitochondrial oxidative processes in IDH1-mutated cancer cells.
Synonyms	(2R)-Octyl-2-HG

Chemical Properties

Molecular Weight	260.33
Formula	C₁₃H₂₄O₅
Cas No.	1391194-67-4
Smiles	C([C@@H](CCC(O)=O)O)(OCCCCCCCC)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (307.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (12.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8413 mL	19.2064 mL	38.4128 mL	192.0639 mL
5 mM	0.7683 mL	3.8413 mL	7.6826 mL	38.4128 mL
10 mM	0.3841 mL	1.9206 mL	3.8413 mL	19.2064 mL
20 mM	0.1921 mL	0.9603 mL	1.9206 mL	9.6032 mL
50 mM	0.0768 mL	0.3841 mL	0.7683 mL	3.8413 mL
100 mM	0.0384 mL	0.1921 mL	0.3841 mL	1.9206 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Octyl-α-hydroxyglutarateOctyl-alpha-hydroxyglutarateOctyl-a-hydroxyglutarateOctyl-2-HG(2R)Octylαhydroxyglutarate(2R) Octyl α hydroxyglutarate