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SHP2-IN-46

Name: SHP2-IN-46
Brand: TargetMol
SKU: T218017
Rating: 4.5 (1 reviews)

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SHP2-IN-46 is an orally active SHP2 inhibitor (IC50= 11.76 μM) that suppresses SHP2 enzyme activity and demonstrates antitumor effects. It inhibits cell proliferation across various cancer cell lines and is applicable for research on lung adenocarcinoma, pancreatic cancer, and hepatoblastoma.

Cas No. 3086360-36-0

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	SHP2-IN-46 is an orally active SHP2 inhibitor (IC50= 11.76 μM) that suppresses SHP2 enzyme activity and demonstrates antitumor effects. It inhibits cell proliferation across various cancer cell lines and is applicable for research on lung adenocarcinoma, pancreatic cancer, and hepatoblastoma.
In vitro	SHP2-IN-46 (Compound 27) effectively inhibits the proliferation of cancer cells A549, MIA PaCa-2, and HepG2, with IC 50 values of 0.24 μM, 0.16 μM, and 0.09 μM, respectively, while showing low cytotoxicity in non-cancerous Vero cells, with an IC 50 value of 42.79 μM. At a concentration of 0.5 μM for 24 hours, SHP2-IN-46 induces S phase cell cycle arrest in HepG2 cells, thereby inhibiting cell proliferation. The compound demonstrates good metabolic stability in human liver microsomes, with a half-life (T 1/2) of 40.63 minutes and intrinsic clearance (CL int) of 34.11 μL/min/mg protein. SHP2-IN-46 also inhibits SHP2 enzyme activity, with an IC 50 value of 11.76 μM in a concentration range of 0.001-100 μM over 90 minutes.
In vivo	SHP2-IN-46 (50-200 mg/kg; p.o.; single dose) has a maximum tolerated dose exceeding 200 mg/kg in ICR mice.

Chemical Properties

Molecular Weight	309.37
Formula	C₁₇H₁₉N₅O
Cas No.	3086360-36-0
Smiles	O=C1N=C(NC(=C1C)C)N2N=C(C=C2NC=3C=CC=CC3C)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: SHP2-IN-46 chemical structure | SHP2-IN-46 in vivo | SHP2-IN-46 in vitro | SHP2-IN-46 formula | SHP2-IN-46 molecular weight