Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1]. |
In vitro | Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) selectively inhibits tumor cell proliferation in a dose- and time-dependent manner across several cell lines, including H22, U251MG, SH-SY5Y, B16, and A549, without impacting the viability of human L02 and HUVEC cells. Optical microscopy reveals that Ph-Ph+ treatment causes tumor cells to shrink and form apoptotic bodies, indicating a mechanism of selective antitumor activity through apoptosis induction. Additionally, Ph-Ph+ exhibits broad-spectrum antibacterial and antifungal effects, effectively combatting drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus. |
In vivo | Tumor-bearing mice, created through subcutaneous transplantation of the mouse hepatoma H22 cell line, exhibited reduced tumor volume and weight following treatment with Ph-Ph+ (2-8 mg/kg; i.v; over 8 days) in a dose-dependent manner [1]. Additionally, in liver cancer animal models with concomitant fungal infection, Ph-Ph+ administration (2-8 mg/kg; i.v; daily for 9 days) not only inhibited the proliferation of hepatoma cells but also alleviated pneumonia and encephalitis induced by Cryptococcus neoformans [1]. |
Molecular Weight | 361.42 |
Formula | C24H17N4+ |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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