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HBV-IN-56

Name: HBV-IN-56
Brand: TargetMol
SKU: T218176
Rating: 4.5 (1 reviews)

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HBV-IN-56 is an orally active inhibitor of HBsAg production. It effectively suppresses HBsAg generation both in vivo and in vitro and is useful for research into chronic hepatitis B virus infection.

HBV-IN-56

Cas No. 2564693-71-4

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	HBV-IN-56 is an orally active inhibitor of HBsAg production. It effectively suppresses HBsAg generation both in vivo and in vitro and is useful for research into chronic hepatitis B virus infection.
In vitro	HBV-IN-56 (compound 31) effectively suppresses HBsAg production in primary human hepatocytes infected with HBV, exhibiting an IC50 of 5 nM, and shows no cytotoxicity even at concentrations up to 15,000 nM. In safety analysis tests, HBV-IN-56 (10-50 μM) displays minimal off-target activity, including no significant kinase inhibition, CYP inhibition, hERG channel activity, or genotoxicity.
In vivo	HBV-IN-56 (compound 31) administered orally at doses of 0.1-1 mg/kg for 21 days reduces and sustains serum HBsAg levels in humanized FRG mice infected with HBV. In Sprague-Dawley rats, oral administration of HBV-IN-56 at 3-60 mg/kg for 91 days results in a dose- and time-dependent decrease in tail NCV and axonal degeneration, with no recovery observed four weeks post-dosing.

Chemical Properties

Molecular Weight	437.89
Formula	C₂₀H₂₀ClNO₆S
Cas No.	2564693-71-4
Smiles	O=C(O)C1=CC2=C(C=3C=C(Cl)C(OCC(C)C)=CC3S(=O)(=O)C2)N(C1=O)C4CC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: HBV-IN-56 in vivo | HBV-IN-56 in vitro | HBV-IN-56 formula | HBV-IN-56 molecular weight