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GLPG3808

Name: GLPG3808
Brand: TargetMol
SKU: T218172
Rating: 4.5 (1 reviews)

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GLPG3808 is an orally active inhibitor of PAPD5/7. It suppresses the expression of HBcAg in various cells infected with HBV. Additionally, GLPG3808 reduces the levels of hepatitis B surface antigen in animal models with HBV infection. This compound is useful for research on hepatitis B virus infections.

GLPG3808

Cas No. 2346450-55-1

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	GLPG3808 is an orally active inhibitor of PAPD5/7. It suppresses the expression of HBcAg in various cells infected with HBV. Additionally, GLPG3808 reduces the levels of hepatitis B surface antigen in animal models with HBV infection. This compound is useful for research on hepatitis B virus infections.
In vitro	GLPG3808 (Compound 31) inhibits the expression of HBcAg in HBV-infected HepG2-NTCP cells, iCell hepatocytes 2.0, and primary human hepatocytes, with IC50 values of 0.12, 5.18 nM, and [under standard conditions] < 0.99 nM; and [under delayed treatment conditions] < 0.88 nM. GLPG3808, at concentrations ranging from 0.25 to 20 μM, completely inhibits probe-induced yeast growth in a yeast three-hybrid competition assay by targeting the PAPD5 and PAPD7 proteins at all tested concentrations.
In vivo	GLPG3808, administered orally at doses ranging from 0.03 to 30 mg/kg once daily over 28 days, reduces serum HBsAg levels by approximately one logarithmic unit in humanized FRG mice infected with HBV. Additionally, GLPG3808 administered at 0.3 to 20 mg/kg orally once daily over 91 days results in a dose-dependent decrease in tail nerve conduction velocity in SD rats.

Chemical Properties

Molecular Weight	475.92
Formula	C₂₄H₂₆ClNO₇
Cas No.	2346450-55-1
Smiles	O=C1N(C2=C([C@@H](OC=3C2=CC(Cl)=C(OCCCOC)C3)C4(C)COC4)C=C1C(O)=O)C5CC5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: GLPG3808 in vivo | GLPG3808 in vitro | GLPG3808 formula | GLPG3808 molecular weight