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BMS-869780
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Catalog No. T218764 Copy Product Info
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BMS-869780 is an orally active non-acidic γ-secretase modulator. It can regulate the activity of γ-secretase, thereby altering the production profile of amyloid-beta peptides. BMS-869780 changes the relative levels of specific amyloid-beta peptide subtypes without reducing the overall production of amyloid-beta. Additionally, it acts synergistically with acidic γ-secretase modulators to inhibit the total production of amyloid-beta in cell cultures.
BMS-869780
Cas No. 1235493-78-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BMS-869780 is an orally active non-acidic γ-secretase modulator. It can regulate the activity of γ-secretase, thereby altering the production profile of amyloid-beta peptides. BMS-869780 changes the relative levels of specific amyloid-beta peptide subtypes without reducing the overall production of amyloid-beta. Additionally, it acts synergistically with acidic γ-secretase modulators to inhibit the total production of amyloid-beta in cell cultures. |
| In vitro | BMS-869780 does not inhibit the production of total Aβ on its own; however, when used in combination with acidic GSM (GSM-2 or GSM-1) in human glioblastoma H4-APPsw cells, it exhibits a strong synergistic inhibitory effect on the production of Aβ1-x and Aβ1-40 (with a combination index as low as 0.05-0.06), and can induce the accumulation of α-CTF. |
| In vivo | Administered orally at a dose of 25 mg/kg, BMS-869780 significantly reduces brain levels of Aβ 1-42 in wild-type C57Bl/6 mice 3 and 6 hours post-treatment, with no significant effect on total brain Aβ 1-x levels. |
| Molecular Weight | 452.91 |
| Formula | C23H22ClFN6O |
| Cas No. | 1235493-78-3 |
| Smiles | N(C=1N=C2[C@@H](CCCCN2N1)C3=CC=C(F)C=C3)C4=CC(OC)=C(C=C4)N5C=NC(Cl)=C5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: BMS-869780 in vivo | BMS-869780 in vitro | BMS-869780 formula | BMS-869780 molecular weight
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