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Phen-DC3 Trifluoromethanesulfonate

Catalog No. T13817L CAS 929895-45-4

Synonyms: Phen-DC3 Triflate

Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).

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Phen-DC3 Trifluoromethanesulfonate Chemical Structure

Phen-DC3 Trifluoromethanesulfonate, CAS 929895-45-4

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Biological Description

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Description	Phen-DC3 Trifluoromethanesulfonate is a G-quadruplex (G4) specific ligand. It also can inhibit FANCJ and DinG helicases (IC50s: 65±6 and 50±10 nM, respectively).
Targets&IC50	DinG helicases (G4 substrate):50±10 nM, FANCJ helicase (G4 substrate):65±6 nM
In vitro	The CEB25-L111(T) array remains stable in wild-type (WT) cells but exhibits instability when treated with Phen-DC3 Trifluoromethanesulfonate or upon PIF1 gene deletion. Similarly, the CEB1-WT array, while generally stable, shows frequent rearrangements after exposure to 10 μM Phen-DC3 Trifluoromethanesulfonate in WT cells. The c-Myc allele is significantly destabilized following Phen-DC3 Trifluoromethanesulfonate treatment or PIF1 deletion, revealing high susceptibility to destabilization under these conditions. Meanwhile, the CEB1-loop CEB25 allele maintains full stability in both scenarios involving PIF1 treatment or in WT cells, indicating a distinct response to these genetic interventions.

Synonyms	Phen-DC3 Triflate
Molecular Weight	848.75
Formula	C36H26F6N6O8S2
CAS No.	929895-45-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 34 mg/mL (40.06 mM)

References and Literature

1. Sanjay Kumar Bharti, et al. Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability. J Biol Chem. 2013 Sep 27; 288(39): 28217–28229. 2. Aurèle Piazza, et al. Short loop length and high thermal stability determine genomic instability induced by G-quadruplex-forming minisatellites. EMBO J. 2015 Jun 12; 34(12): 1718–1734.

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Keywords

Phen-DC3 Trifluoromethanesulfonate 929895-45-4 Others PhenDC3 Trifluoromethanesulfonate Phen-DC-3 Trifluoromethanesulfonate Phen-DC3 Triflate Phen DC3 Trifluoromethanesulfonate inhibitor inhibit

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