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Diglycyl-histidine

Catalog No. T20382 CAS 7451-76-5

Synonyms: NSC334195, NSC-334195, Gly-gly-his, Glycylglycyl-L-histidine, NSC 334195

Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.

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Diglycyl-histidine, CAS 7451-76-5

Pack Size	Availability	Price/USD	Quantity
100 mg	Inquiry	$ 279.00
500 mg	Inquiry	$ 632.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.

Synonyms	NSC334195, NSC-334195, Gly-gly-his, Glycylglycyl-L-histidine, NSC 334195
Molecular Weight	269.26
Formula	C10H15N5O4
CAS No.	7451-76-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Hu X, Zhang Q, Wang W, Yuan Z, Zhu X, Chen B, Chen X. Tripeptide GGH as the Inhibitor of Copper-Amyloid-β-Mediated Redox Reaction and Toxicity. ACS Chem Neurosci. 2016 Sep 21;7(9):1255-63. doi: 10.1021/acschemneuro.6b00145. Epub 2016 Aug 3. PubMed PMID: 27433833. 2. Gerlich M, Neumann S. MetFusion: integration of compound identification strategies. J Mass Spectrom. 2013 Mar;48(3):291-8. doi: 10.1002/jms.3123. PubMed PMID: 23494783. 3. Joyner JC, Hodnick WF, Cowan AS, Tamuly D, Boyd R, Cowan JA. Antimicrobial metallopeptides with broad nuclease and ribonuclease activity. Chem Commun (Camb). 2013 Mar 14;49(21):2118-20. doi: 10.1039/c3cc38977d. Epub 2013 Feb 5. PubMed PMID: 23380915; PubMed Central PMCID: PMC3632407. 4. Gruchlik A, Jurzak M, Chodurek E, Dzierzewicz Z. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69(6):1303-6. PubMed PMID: 23285694.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Diglycyl-histidine 7451-76-5 NSC334195 Diglycyl histidine NSC-334195 Gly-gly-his Glycylglycyl-L-histidine Diglycylhistidine NSC 334195 inhibitor inhibit

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