Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,350.00 | |
50 mg | 6-8 weeks | $ 1,760.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | (S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX). |
In vitro | (S)-Carvedilol exhibits beta-receptor blocking activity that is approximately 100 times more potent than that of its enantiomer (R)-Carvedilol, though both enantiomers demonstrate equal efficacy as alpha-blockers. Treatment with (S)-Carvedilol markedly enhances the expression of p-eNOS in HUVECs. Additionally, (S)-Carvedilol effectively reduces Doxorubicin (DOX)-induced cell death, apoptotic alterations, and depletion of mitochondrial membrane potential. It also mitigates oxidative stress by increasing superoxide dismutase and catalase activity, while reducing malondialdehyde levels and reactive oxygen species, mediated through the PI3K/AKT/eNOS pathway in vitro. |
Synonyms | (S)-BM 14190 |
Molecular Weight | 406.47 |
Formula | C24H26N2O4 |
CAS No. | 95094-00-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
(S)-Carvedilol 95094-00-1 Others BM-14190 Carvedilol BM 14190 (S)-BM 14190 (S)Carvedilol (S) Carvedilol BM14190 inhibitor inhibit