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SiR-COOH

Catalog No. T38851 CAS 1418275-26-9

SiR-COOH enables tracking of the model therapeutic drug's intracellular location in GFP cells, characterized by absorption (Abs) at 645 nm and emission (Em) at 676 nm.

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SiR-COOH, CAS 1418275-26-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00
500 mg	In stock	$ 4,900.00

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Purity: 97.23%

Purity: 92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SiR-COOH enables tracking of the model therapeutic drug's intracellular location in GFP cells, characterized by absorption (Abs) at 645 nm and emission (Em) at 676 nm.

In vitro

SiR-COOH can be utilized for conjugating inhibitors like UNC2025 (Mer inhibitor). Sir-COOH is particularly advantageous for small-molecule probes: it displays bright, photostable fluorescence at near-infrared wavelengths, ideal for deep-tissue imaging; exhibits robust fluorescence in physiological environments with minimal toxicity; is suitable for super-resolution microscopy; and possesses an optimal level of hydrophilicity for live-cell imaging.[2]

Molecular Weight	472.61
Formula	C27H28N2O4Si
CAS No.	1418275-26-9

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (105.8 mM)

References and Literature

1. Eunha Kim, et al. Red Si-rhodamine drug conjugates enable imaging in GFP cells. Chem Commun (Camb). 2014 May 4;50(34):4504-7. 2. Miles A Miller, et al. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19;54(1):42-45.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SiR-COOH 1418275-26-9 SiRCOOH SiR COOH inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.