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difelikefalin acetate(1024828-77-0 Free base)

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Catalog No. TP2485Cas No. 2803411-76-7

Difelikefalin acetate (CR 845 acetate) is a peripherally restricted kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain.

difelikefalin acetate(1024828-77-0 Free base)
Other Forms of difelikefalin acetate(1024828-77-0 Free base):

difelikefalin acetate(1024828-77-0 Free base)

🥰Excellent
Purity: 96.94%
Catalog No. TP2485Cas No. 2803411-76-7
Difelikefalin acetate (CR 845 acetate) is a peripherally restricted kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$100-In Stock
5 mg$208-In Stock
10 mg$327-In Stock
25 mg$527-In Stock
50 mg$713-In Stock
100 mg$978-In Stock
200 mg$1,290-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.94%
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Product Introduction

Bioactivity
Description
Difelikefalin acetate (CR 845 acetate) is a peripherally restricted kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain.
In vitro
Difelikefalin (CR-845; FE-202845) does not penetrate the blood-brain barrier. Difelikefalin does not bind to mu opioid receptors or any other receptors beside KORs[1].
Chemical Properties
Molecular Weight739.9
FormulaC38H57N7O8
Cas No.2803411-76-7
SmilesCC(O)=O.O=C(C1(N)CCN(C([C@@H](CCCCN)NC([C@@H](CC(C)C)NC([C@@H](CC2=CC=CC=C2)NC([C@@H](CC3=CC=CC=C3)N)=O)=O)=O)=O)CC1)O
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

OpioidReceptorOpioid Receptorkappa opioid receptordifelikefalin acetate(1024828-77-0 Free base)difelikefalin acetate(1024828770 Free base)difelikefalin acetate(1024828 77 0 Free base)
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