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TM38837

Catalog No. T8511 CAS 1253641-65-4

TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.

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TM38837, CAS 1253641-65-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
5 mg	In stock	$ 126.00
10 mg	In stock	$ 166.00
25 mg	In stock	$ 287.00
50 mg	In stock	$ 450.00
100 mg	In stock	$ 663.00
1 mL * 10 mM (in DMSO)	In stock	$ 166.00

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Purity: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.

In vivo

TM38837, a novel, largely peripherally restricted CB1 antagonist, in terms of fear-promoting consequences of systemic vs. intracerebral injections.?Different groups of male C57BL/6 N mice underwent auditory fear conditioning, followed by re-exposure to the tone.?Mice were treated per os (p.o.) with TM38837 (10, 30, or 100 mg/kg), rimonabant (10 mg/kg;?a brain penetrating CB1 antagonist/inverse agonist which served as a positive control), or vehicle, 2 h prior the tone presentation.?Only the high dose of TM38837 (100 mg/kg) induced a significant increase in freezing behavior, similar to that induced by rimonabant (10 mg/kg) (p

Molecular Weight	617.51
Formula	C30H25Cl2F3N4OS
CAS No.	1253641-65-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (64.77 mM), Sonification is recommended.

References and Literature

1. Micale V, et al. The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows ReducedFear-Promoting Effects in Mice. Front Pharmacol. 2019 Mar 20;10:207. 2. Akihiro, Takano, Balázs, et al. Low brain CB1 receptor occupancy by a second generation CB1 receptor antagonist TM38837 in comparison with rimonabant in nonhuman primates: A PET study[J]. Synapse, 2013.

Citations

1. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Obesity Compound Library Covalent Inhibitor Library Anti-Fibrosis Compound Library Anti-Diabetic Compound Library Neuronal Signaling Compound Library

Related Products

Related compounds with same targets

CB1R Allosteric modulator 3 CB1 antagonist 1 Hemopressin (human, mouse) acetate CID 16020046 AM1241 Bay 59-3074 GW 833972A Rimonabant hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TM38837 1253641-65-4 GPCR/G Protein Cannabinoid Receptor peripheral CB1 TM-38837 antiobesity TM 38837 inhibit fat Inhibitor metabolic fear inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.