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T-2000

Catalog No. T28900 CAS 97846-21-4

Synonyms: DMMDPB

T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and essential tremor.

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T-2000, CAS 97846-21-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 142.00
5 mg	In stock	$ 350.00
10 mg	In stock	$ 530.00
25 mg	In stock	$ 859.00
50 mg	In stock	$ 1,180.00
100 mg	In stock	$ 1,590.00
500 mg	In stock	$ 3,190.00

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Purity: 98.75%

Biological Description

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Description

T-2000 (DMMDPB) is a GABA receptor agonist that can be used to study myoclonus and essential tremor.

In vivo

T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid; DMMDPB) on essential tremor, given in twice daily doses of 400 and 300 mg, In the first study of 12 patients treated with 400 mg or placebo twice daily for 14 days, the mean change from baseline at day 14 was 19.3 (P < 0.0001) in the treated group and 9.0 (P = 0.0121) in the control group. Using a two-factor mixed ANOVA model to evaluate within-group and between-group changes, the effect of T2000 was significantly different from that of the placebo group (P = 0.03). In the second study of 22 patients treated with 300 mg of T2000 or placebo twice daily for 20 days, statistically significant changes were seen in treated patients compared to baseline, but the ANOVA model did not demonstrate a significant treatment effect of T2000 compared to placebo. When the treated groups from each study are compared, the 800-mg daily group is significantly different from the 600-mg daily group (P = 0.02).[2]

Synonyms	DMMDPB
Molecular Weight	368.38
Formula	C20H20N2O5
CAS No.	97846-21-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (149.3 mM)

References and Literature

1. Hadj Tahar A, et al. Efficacy and safety of T2000 in older patients with essential tremor. Parkinsonism Relat Disord. 2013 Apr;19(4):485-6. 2. Melmed C, et al. Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid). Mov Disord. 2007 Apr 15;22(5):723-7.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

T-2000 97846-21-4 Membrane transporter/Ion channel Neuroscience GABA Receptor T2000 DMMDPB T 2000 inhibitor inhibit

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