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Pralmorelin

Catalog No. T5025 CAS 158861-67-7

Pralmorelin is an oral active synthetic peptide analogue of MEK. Pralmorelin is an auxin releasing peptide/growth hormone secretory receptor agonist, can selectively stimulate ghrelin receptor and cause growth hormone release, has shown anti-inflammatory activity.

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Pralmorelin, CAS 158861-67-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pralmorelin is an oral active synthetic peptide analogue of MEK. Pralmorelin is an auxin releasing peptide/growth hormone secretory receptor agonist, can selectively stimulate ghrelin receptor and cause growth hormone release, has shown anti-inflammatory activity.
In vitro	An anti-inflammatory role for ghrelin (GHRP-2) in PKC-mediated inflammation of granulosa cells, at least in part, due to its inhibitory effect on PKC-induced activation of p38, JNK and NF-κB, possibly by targeting to MKP-1 and PP2A[1].
In vivo	An insulin tolerance test (ITT), CRH stimulation test, and GHRP-2 test on 47 patients suspected of having a hypothalamo-pituitary disorder were preformed. The results indicate that the GHRP-2 test may induce ACTH secretion from the pituitary gland through direct stimulation[2].

Molecular Weight	817.97
Formula	C45H55N9O6
CAS No.	158861-67-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Chao Y N , Sun D , Peng Y C , et al. Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells[J]. International Journal of Molecular Sciences, 2016. 2. Arimura H , Hashiguchi H , Yamamoto K , et al. Investigation of the clinical significance of the growth hormone-releasing peptide-2 test for the diagnosis of secondary adrenal failure[J]. Endocrine Journal, 2016, 63(6):533-544.

Related Products

Related compounds with same targets

Capromorelin Tartrate CJC-1295 acetate(863288-34-0 free base) Obestatin (rat) acetate Human growth hormone-releasing factor acetate AnaMorelin hydrochloride Ibutamoren Mesylate Pralmorelin acetate 158861-67-7(free base） TC-G-1008

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Keywords

Pralmorelin 158861-67-7 GPCR/G Protein GHSR Inhibitor inhibitor inhibit

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