Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 30.00 | |
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 85.00 | |
25 mg | In stock | $ 133.00 | |
50 mg | In stock | $ 195.00 | |
100 mg | In stock | $ 297.00 | |
200 mg | In stock | $ 488.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor |
In vitro | Olmutinib at 3 μM significantly reversed drug resistance mediated by ABCG2, but not by ABCB1 and ABCC1, by antagonizing the drug efflux function in ABCG2-overexpressing cells.?In addition, olmutinib at reversal concentration affected neither the protein expression level nor the localization of ABCG2.?The results observed from the accumulation/efflux study of olmutinib showed that olmutinib reversed ABCG2-mediated MDR with an increasing intracellular drug accumulation due to inhibited drug efflux.?We also had consistent results with the ATPase assay that olmutinib stimulated ATPase activity of ABCG2 up to 3.5-fold.?Additionally, the molecular interaction between olmutinib and ABCG2 was identified by docking simulation.?Olmutinib not only interacts directly with ABCG2 but also works as a competitive inhibitor of the transport protein[1] |
Synonyms | HM61713, BI1482694 |
Molecular Weight | 486.59 |
Formula | C26H26N6O2S |
CAS No. | 1802181-20-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (113.03 mM)
You can also refer to dose conversion for different animals. More
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Olmutinib 1802181-20-9 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HM 61713 HM61713 HM-61713 BI1482694 BI-1482694 BI 1482694 1353550-13-6 inhibitor inhibit