Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,230.00 | |
50 mg | 6-8 weeks | $ 1,610.00 | |
100 mg | 6-8 weeks | $ 2,390.00 |
Description | IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor. |
In vitro | IZCZ-3 induces only weak growth inhibition in the BJ fibroblasts (IC50=15.9 μM) and mouse mesangial cells (IC50=15.6 μM), suggesting that IZCZ-3 is more effective against cancer cells than against c-MYC-independent normal cells. IZCZ-3 (0-5 μM; 12 hours) induces an apparent accumulation of cells in the G0/G1 phase in SiHa cells in a dose-dependent manner.IZCZ-3 (2.1 μM-15.9 μM; 24 hours) significantly inhibits SiHa, HeLa, Huh7, and A375 cancer cell proliferation (IC50s of 3.3, 2.1,4.1, and 4.2 μM, respectively). |
In vivo | IZCZ-3 inhibits tumor growth in BALB/c nude mice with SiHa human cervical squamous cancer xenograft. |
Molecular Weight | 715.93 |
Formula | C46H49N7O |
CAS No. | 2223019-53-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (6.98 mM), Sonication and heating to 80℃ are recommended.
You can also refer to dose conversion for different animals. More
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IZCZ-3 2223019-53-0 Others IZCZ3 IZCZ 3 inhibitor inhibit