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Elamipretide

Catalog No. TP1095   CAS 736992-21-5
Synonyms: MTP-131, RX-31, SS-31

Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. Elamipretide is a potential therapeutic agent in the rare disease of Barnes syndrome.

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Elamipretide Chemical Structure
Elamipretide, CAS 736992-21-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 50.00
2 mg In stock $ 73.00
5 mg In stock $ 133.00
10 mg In stock $ 208.00
25 mg In stock $ 375.00
50 mg In stock $ 562.00
100 mg In stock $ 719.00
200 mg In stock $ 996.00
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Purity: 99.76%
Purity: 98.53%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. Elamipretide is a potential therapeutic agent in the rare disease of Barnes syndrome.
In vitro METHODS: Rat insulinoma cells, INS1, were treated with Elamipretide (1-10 μM) for 20 h. Cellular mitochondria were detected by Immunofluorescence.
RESULTS: Elamipretide prevented mitochondrial breaks induced by nutrient overload, and at the same time had no effect on the mitochondrial morphology of healthy INS1 cells. [1]
METHODS: Immortalized human trabecular meshwork cells iHTM and glaucomatous human trabecular cell line GTM3 cells were pretreated with Elamipretide (0.01-1 μM) for 1 h, followed by incubation with H2O2 (200 μM) for 24 h, and LDH release was detected by calorimetric assay.
RESULTS: Incubation with H2O2 resulted in a significant increase in LDH release in iHTM and GTM3 cells, and pretreatment with MTP-131 dose-dependently inhibited LDH release. [2]
In vivo METHODS: To investigate the effects on cognitive sequelae of inflammation and oxidative stress, Elamipretide (5 mg/kg) was administered intraperitoneally to LPS-injected C57BL/6 mice once daily for three days.
RESULTS: LPS-induced memory impairment could be attenuated by the mitochondria-targeted antioxidant Elamipretide. [3]
METHODS: To test the phenotypic effects on aging in mice, Elamipretide (3 mg/kg) was injected subcutaneously into C57BL/6 mice five times a week for ten months.
RESULTS: Elamipretide enhanced healthy aging and cardiac function in both male and female mice, although the specific effects on function varied by sex. In females, the treatment improved cognition and maintained body composition, while in males, rotisserie performance was preserved. [4]
Synonyms MTP-131, RX-31, SS-31
Molecular Weight 639.79
Formula C32H49N9O5
CAS No. 736992-21-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

ddH2O: 100 mg/mL (156.30 mM)

DMSO: 29 mg/mL (45.33 mM)

TargetMolReferences and Literature

1. Petcherski A, et al. Elamipretide Promotes Mitophagosome Formation and Prevents Its Reduction Induced by Nutrient Excess in INS1 β-cells. J Mol Biol. 2018 Dec 7;430(24):4823-4833. 2. Chen M, et al. Mitochondria-targeted peptide MTP-131 alleviates mitochondrial dysfunction and oxidative damage in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011 Sep 1;52(10):7027-37. 3. Zhao W, et al. Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice. J Neuroinflammation. 2019 Nov 20;16(1):230. 4. Nickel K, et al. Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice. Aging Pathobiol Ther. 2022;4(3):76-83.

TargetMolCitations

1. Suo M, Qi Y, Liu L, et al. SS31 Alleviates Pressure Overload-Induced Heart Failure Caused by Sirt3-Mediated Mitochondrial Fusion. Frontiers in Cardiovascular Medicine. 2022.9 2. Yao S, Wu D, Hu X, et al.Platelet Membrane-Coated Bio-Nanoparticles of Indocyanine Green/Elamipretide for NIR Diagnosis and Antioxidant Therapy in Acute Kidney Injury.Acta Biomaterialia.2023 3. Hao Y, Fan Y, Feng J, et al.ALCAT1-mediated abnormal cardiolipin remodelling promotes mitochondrial injury in podocytes in diabetic kidney disease.Cell Communication and Signaling.2024, 22(1): 1-20. 4. Ji Y, Ma Y, Ma Y, et al.SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice.Inflammation Research.2024: 1-14.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Human Metabolite Library ReFRAME Related Library

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Keywords

Elamipretide 736992-21-5 Others SS 31 SS31 MTP-131 RX-31 RX 31 MTP 131 MTP131 SS-31 RX31 inhibitor inhibit

 

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