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Carisbamate

Catalog No. T30748 CAS 194085-75-1

Synonyms: JNJ10234094, JNJ-10234094, RWJ 333369, RWJ-333369, RWJ333369

CarisbAMate (JNJ-10234094, RWJ 333369, YKP-509) is an antiepileptic drug candidate.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Carisbamate, CAS 194085-75-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 916.00
50 mg	6-8 weeks	$ 1,190.00
100 mg	6-8 weeks	$ 1,990.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

CarisbAMate (JNJ-10234094, RWJ 333369, YKP-509) is an antiepileptic drug candidate.

Synonyms	JNJ10234094, JNJ-10234094, RWJ 333369, RWJ-333369, RWJ333369
Molecular Weight	215.63
Formula	C9H10ClNO3
CAS No.	194085-75-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mangubat EZ, Kellogg RG, Harris TJ Jr, Rossi MA. On-demand pulsatile intracerebral delivery of carisbamate with closed-loop direct neurostimulation therapy in an electrically induced self-sustained focal-onset epilepsy rat model. J Neurosurg. 2015 Jun;122(6):1283-92. doi: 10.3171/2015.1.JNS14946. Epub 2015 Feb 27. PubMed PMID: 25723302. 2. Hadera MG, Faure JB, Berggaard N, Tefera TW, Nehlig A, Sonnewald U. The anticonvulsant actions of carisbamate associate with alterations in astrocyte glutamine metabolism in the lithium-pilocarpine epilepsy model. J Neurochem. 2014 Oct 26;132(5):532-545. doi: 10.1111/jnc.12977. [Epub ahead of print] PubMed PMID: 25345404. 3. Shim S, El Mansari M, Blier P. Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain. J Pharmacol Exp Ther. 2013 Nov;347(2):487-96. doi: 10.1124/jpet.113.203315. Epub 2013 Aug 28. PubMed PMID: 23986541. 4. Smith T, DiBernardo A, Shi Y, Todd MJ, Brashear HR, Ford LM. Efficacy and safety of carisbamate in patients with diabetic neuropathy or postherpetic neuralgia: results from 3 randomized, double-blind placebo-controlled trials. Pain Pract. 2014 Apr;14(4):332-42. doi: 10.1111/papr.12080. Epub 2013 May 22. PubMed PMID: 23692321.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Molecular Weight Calculator

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Mass of a compound required to prepare a solution of known volume and concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Carisbamate 194085-75-1 JNJ10234094 JNJ-10234094 JNJ 10234094 RWJ 333369 RWJ-333369 RWJ333369 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.