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α-Synuclein (61-75)

Catalog No. T40541 CAS 440645-08-9

α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disease (PD).

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α-Synuclein (61-75), CAS 440645-08-9

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Description

In vitro

Lewy bodies containing α-Synuclein are key neuropathological indicators of Parkinson's Disease (PD), with mutations in α-Synuclein (A30P, E46K, H50Q, G51D, A53E, A53T), along with gene duplications and triplications of α-Synuclein, directly causing PD. Additionally, polymorphisms in α-Synuclein gene regulatory elements increase susceptibility to PD and are associated with early disease onset. The non-Aβ-amyloid component (NAC) of α-Synuclein, characterized by its hydrophobic and aggregation-prone nature, contrasts with its mouse counterpart and the analogous segment in human β-Synuclein, which is not prone to aggregation. Interestingly, β-Synuclein shares a greater homology with α-Synuclein in the N-terminal sequences (74%) compared to γ-Synuclein (67%)[1].

Molecular Weight	1430.58
Formula	C60H103N17O23
CAS No.	440645-08-9

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Jacqueline Burré, et al. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a024091. 2. Nelson Ferreira, et al. Trans-synaptic spreading of alpha-synuclein pathology through sensory afferents leads to sensory nerve degeneration and neuropathic pain. Acta Neuropathol Commun. 2021 Feb 25;9(1):31.

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Keywords

α-Synuclein (61-75) 440645-08-9 α Synuclein (61 75) alpha-Synuclein a-Synuclein α-Synuclein αSynuclein (6175) inhibitor inhibit

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