Drug-induced Liver Injury (DILI) Compound Library

Catalog No. L5510

Library Compound List Excel SDF

Adverse drug events such as cardiotoxicity, hepatotoxicity and other organ toxicities, keep surfacing in the clinic and idiosyncratic drug toxicity continues to haunt the drug development process. Drug-induced liver injury (DILI) is common and nearly all classes of medications can cause liver disease. Although cardiotoxicity remains one of the main reasons for drug development termination, both during pre-clinical and clinical stages, DILI is the most common reason cited for withdrawal of an approved drug. The reason for this most likely lies in the fact that significant advancement in understanding the mechanistic basis of cardiotoxicity but the imperfect prediction of DILI risk.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural and functional integrity of the liver (e.g., mitochondrial dysfunction); production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

TargetMol’s Drug-induced Liver Injury Compound Library collects 1001 hepatotoxicity causing compounds, including anti-cancer drugs, antibiotics, antituberculosis agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc. It is not only a powerful tool for DILI research and other drug toxicities but is of crucial value in understanding the mechanisms of DILI, identifying biomarkers for early DILI prediction, and allowing timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

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please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

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Product Description

A unique collection of 1001 hepatotoxicity causing compounds, a powerful tool for drug toxicity study, can be used for HTS and HCS screening；
Include anti-cancer drugs, antibiotics, antituberculotic agents, antiretrovirals, antiepileptic agents, and cardiac medications, etc.；
Diversified in toxicities: Steatosis, Mitochondrial toxicity, cholestasis, drug allergy (hypersensitivity), etc.;
NMR and HPLC validated to ensure high purity and quality.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

10. Blood. 2021, 137(11): 1478-1490. 11. Nucleic Acids Research. 2021. 12. Nature Communications. 2023, 14(1): 7574. 13. Advanced Science. 2020, 7(16): 2000925. 14. Angewandte Chemie. 2021. 15. Acta Pharmaceutica Sinica B. 2022. 16. Protein & Cell. 2021, 12(11): 877-888. 17. Bone Research. 2023, 11(1): 54. 18. Pharmacology & Therapeutics. (2021): 107930. 19. Nature Communications. 2021, 12(1): 1-12. 20. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Antibacterial (248)

Autophagy (193)

Antibiotic (172)

Apoptosis (148)

5-HT Receptor (54)

Endogenous Metabolite (50)

DNA/RNA Synthesis (47)

Adrenergic Receptor (45)

Dopamine Receptor (44)

AChR (43)

HIV Protease (42)

Parasite (42)

COX (41)

Histamine Receptor (36)

Potassium Channel (28)

Sodium Channel (26)

Topoisomerase (25)

Antifungal (24)

P450 (24)

Ferroptosis (23)

Mitophagy (22)

Nucleoside Antimetabolite/Analog (22)

Calcium Channel (21)

VEGFR (19)

RAAS (19)

SARS-CoV (18)

Microtubule Associated (17)

Reverse Transcriptase (17)

PDGFR (17)

Serotonin Transporter (17)

Reactive Oxygen Species (16)

Dehydrogenase (16)

c-Kit (16)

Influenza Virus (15)

Estrogen/progestogen Receptor (15)

DNA Alkylator/Crosslinker (14)

HDAC (13)

PDE (13)

Norepinephrine (13)

GABA Receptor (13)

HSV (11)

FLT (11)

EGFR (11)

PPAR (11)

ROS (10)

NF-κB (10)

MAO (10)

MRP (9)

ribosome (9)

Virus Protease (9)

HCV Protease (9)

Androgen Receptor (8)

Raf (8)

Bcr-Abl (8)

ALK (8)

Src (8)

HMG-CoA Reductase (8)

Antifolate (8)

Antifection (8)

FGFR (8)

Estrogen Receptor/ERR (8)

DNA Alkylation (7)

Opioid Receptor (7)

TNF (7)

Tyrosine Kinases (7)

CDK (7)

Proteasome (7)

PI3K (7)

HBV (7)

PKC (7)

Phosphatase (6)

c-RET (6)

mTOR (6)

Progesterone Receptor (6)

Retinoid Receptor (6)

Glucocorticoid Receptor (6)

NMDAR (6)

Carbonic Anhydrase (6)

MMP (6)

CaMK (6)

Adenosine Receptor (6)

MEK (5)

Proton pump (5)

TLR (5)

Antiviral (5)

HIF/HIF Prolyl-Hydroxylase (5)

Trk receptor (5)

Nrf2 (5)

iGluR (5)

GluR (5)

DHFR (5)

Thrombin (5)

DNA Methyltransferase (5)

P-gp (5)

Fatty Acid Synthase (4)

Lipoxygenase (4)

TGF-beta/Smad (4)

BTK (4)

PARP (4)

AChE (4)

Prostaglandin Receptor (4)

ATPase (4)

Monoamine Oxidase (4)

Transferase (4)

ROS Kinase (4)

TAM Receptor (4)

c-Met/HGFR (4)

Antioxidant (4)

P2Y Receptor (4)

Reductase (4)

Glutathione Peroxidase (4)

ABC (4)

Phospholipase (4)

AMPK (4)

Syk (3)

Hydroxylase (3)

Interleukin (3)

Ligand for E3 Ligase (3)

AhR (3)

Xanthine Oxidase (3)

STAT (3)

Akt (3)

HER (3)

Endothelin Receptor (3)

Thyroid hormone receptor(THR) (3)

TRP/TRPV Channel (3)

DPP-4 (3)

Monoamine Transporter (3)

Molecular Glues (3)

Gamma-secretase (3)

Factor Xa (3)

Histone Methyltransferase (3)

Melatonin Receptor (3)

JAK (3)

Chloride channel (3)

Hedgehog/Smoothened (3)

CAT (3)

FAK (2)

CRISPR/Cas9 (2)

UGT (2)

Aminopeptidase (2)

Pyroptosis (2)

RSV (2)

GST (2)

Beta Amyloid (2)

CCR (2)

c-Fms (2)

S1P Receptor (2)

Serine/threonin kinase (2)

Rho (2)

GNRH Receptor (2)

Adenosine deaminase (2)

CFTR (2)

NADPH (2)

LPL Receptor (2)

YAP (2)

Ligands for Target Protein for PROTAC (2)

Sigma receptor (2)

HSP (2)

IL Receptor (2)

NO Synthase (2)

MT Receptor (2)

Drug Metabolite (2)

DNA (2)

Telomerase (2)

Isocitrate Dehydrogenase (IDH) (2)

Mitochondrial Metabolism (2)

IGF-1R (2)

BCL (2)

DNA gyrase (2)

Smo (2)

OAT (2)

Hydrogenase (1)

DUB (1)

PAK (1)

JNK (1)

CETP (1)

ATTECs (1)

Neurokinin receptor (1)

Platelet aggregation (1)

Histone Demethylase (1)

Mdm2 (1)

Anti-infection (1)

Somatostatin (1)

Chk (1)

Integrase (1)

Aurora Kinase (1)

NADPH-oxidase (1)

NOD-like Receptor (NLR) (1)

Ras (1)

p38 MAPK (1)

Integrin (1)

VDA (1)

ACK (1)

Epigenetic Reader Domain (1)

NPC1L1 (1)

Tyrosinase (1)

Protease-activated Receptor (1)

ROR (1)

MALT (1)

cholecystokinin (1)

GRK (1)

GSK-3 (1)

RANKL/RANK (1)

Annexin A (1)

IRE1 (1)

CSF-1R (1)

Free radical scavengers (1)

Sirtuin (1)

Ephrin Receptor (1)

Decarboxylase (1)

IAP (1)

Aryl Hydrocarbon Receptor (1)

MAPK (1)

ERK (1)

IκB/IKK (1)

Beta-Secretase (1)

ROCK (1)

GlyT (1)

CaSR (1)

Hck (1)

PLK (1)

Hexokinase (1)

PKA (1)

Wnt/beta-catenin (1)

Glucosidase (1)

Oxytocin Receptor (1)

Serine Protease (1)

Caspase (1)

GPR (1)

Aromatase (1)

Cysteine Protease (1)

FXR (1)

Lipid (1)

Leukotriene Receptor (1)

Guanylate cyclase (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty