Cart
Compound Libraries Glycometabolism Compound Library

Glycometabolism Compound Library

Catalog No. L2520
  Library Compound List   Excel SDF

Glucose and glycogen are initial materials involved in the glycometabolism. A chronically irregular diet could result in the disorders of glycometabolism, which was manifested by the gradual deterioration of glucose tolerance over time, leading to the increased fasting blood glucose or impaired glucose tolerance. The clinical manifestations of glycometabolism-related disorder are hyperglycemia or hypoglycemia, which might eventually contribute to some serious diseases, such as diabetes, G6PD deficiency, obesity and malnutrition.

In addition, favored glycolysis under aerobic conditions (aerobic glycolysis), or the Warburg effect, the transition from oxidative phosphorylation to glycolysis, accompanied by the accumulation of lactate by-products in the surrounding microenvironment and 20-30 times faster rate of glucose metabolism than the complete oxidation of glucose in the mitochondria, represents the most typical change observed in the metabolism of cancer cells. Therefore, a key to selective killing of cancer cells lies in their dependence on glycolysis. Targeting tumor cell metabolism has become a successful approach to the prevention or treatment of cancer. Most efforts have focused on the use of small molecules to inhibit the function of metabolic enzymes, which has been comprehensively reviewed elsewhere. Increasing evidence supports many glycolytic enzymes and transporters as candidates for cancer treatment.

TargetMol’s Glycometabolism Compound Library collects 638 glycometabolism-related compounds, targeting GLUTs, Hexokinase(HK), Pyruvate Kinase(PK ), phosphofructokinase(PFK), IDH1/2, LDH, AMPK, etc. It is a powerful tool for research in glycometabolism-related disorders and cancer.

Pack Size Price/USD
100 μL * 10 mM (in DMSO) 10374.00
250 μL * 10 mM (in DMSO) 17370.00
1 mg 17370.00
Request Library
Get quote

Product Description

  • 638 glycometabolism-related comounds, can be used for HTS and HCT;
  • Targets contain GLUTs、Hexokinase(HK)、Pyruvate Kinase(PK)、phosphofructokinase(PFK)、IDH1/2、LDH、AMPK, etc.;
  • Detailed compound information with structure, target, and biological activity description;
  • NMR and HPLC/LCMS validated to ensure high purity and quality.
  • All compounds are in stock.

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
Request Library Compound List (L2520)

Library Composition

PI3K (105)
PPAR (68)
mTOR (53)
Akt (39)
AMPK (39)
GSK-3 (35)
Glucokinase (29)
Phosphatase (29)
Carbonic Anhydrase (28)
DNA-PK (27)
HIF (25)
p53 (22)
S6 Kinase (19)
ATM/ATR (19)
Dehydrogenase (18)
DPP-4 (16)
IGF-1R (16)
CDK (14)
SGLT (13)
NF-κB (12)
Mitochondrial Metabolism (11)
Reductase (11)
Autophagy (11)
HIF/HIF Prolyl-Hydroxylase (11)
Mdm2 (10)
PKC (9)
COX (9)
Glucocorticoid Receptor (8)
PDK (8)
PKM (7)
Src (7)
transporter (7)
VEGFR (7)
Wnt/beta-catenin (7)
ERK (7)
Potassium Channel (6)
NAMPT (6)
P450 (5)
PKA (5)
MEK (5)
MMP (5)
Tyrosinase (5)
STAT (5)
SGK (5)
Histone Methyltransferase (5)
EGFR (4)
Endogenous Metabolite (4)
FLT (4)
Bcr-Abl (4)
Apoptosis (4)
AChR (4)
Adrenergic Receptor (4)
TNF (4)
ROCK (4)
NADPH (4)
p38 MAPK (4)
PDE (3)
PDGFR (3)
NADPH-oxidase (3)
ALK (3)
ATPase (3)
Calcium Channel (3)
Casein Kinase (3)
c-Met/HGFR (3)
Chk (3)
FGFR (3)
Estrogen/progestogen Receptor (3)
FAK (2)
GluR (2)
GABA Receptor (2)
Hck (2)
IL Receptor (2)
Hexokinase (2)
HSV (2)
Integrin (2)
JNK (2)
Chloride channel (2)
Cysteine Protease (2)
BCL (2)
c-Fms (2)
Aurora Kinase (2)
Androgen Receptor (2)
Antioxidant (2)
MELK (2)
Microtubule Associated (2)
Lipoxygenase (2)
LRRK2 (2)
PARP (2)
PI4K (2)
Raf (2)
Serine Protease (2)
SIK (2)
Sirtuin (2)
Sodium Channel (2)
Syk (2)
Tyrosine Kinases (2)
Trk receptor (2)
Thrombin (1)
Sigma receptor (1)
ROS (1)
S1P Receptor (1)
Salt-Inducible Kinase (1)
Retinoid Receptor (1)
Reverse Transcriptase (1)
Proteasome (1)
PTEN (1)
PTP1B (1)
PYK2 (1)
PERK (1)
Phospholipase (1)
Phosphorylase (1)
PAK (1)
lysosomal autophagy (1)
MAPK (1)
NOS (1)
MPO (1)
MRP (1)
Mitophagy (1)
MLK (1)
ABC (1)
Antibiotic (1)
AhR (1)
BACE (1)
Apoptosis inducer (1)
Arginase (1)
ATP Citrate Lyase (1)
cell cycle arrest (1)
c-RET (1)
CSF-1R (1)
cholecystokinin (1)
c-Kit (1)
LDL (1)
Isocitrate Dehydrogenase (IDH) (1)
Immunology & Inflammation related (1)
HDAC (1)
Hedgehog/Smoothened (1)
HIV Protease (1)
Histone Demethylase (1)
Glucagon Receptor (1)
Epigenetic Reader Domain (1)
GR (1)
Fatty Acid Synthase (1)
E1/E2/E3 Enzyme (1)
DHFR (1)
DNA Alkylation (1)